OBJECTIVE: To estimate the risk of bloodstream infection associated with catheter dwell time in infants. DESIGN: Retrospective study. SETTING: Duke University Medical Center neonatal intensive care unit, an academic, level 3 nursery in Durham, North Carolina. METHODS: A case of catheter-associated bloodstream infection was defined as one that occurred in an infant whose culture-positive blood sample was collected more than 24 hours after catheter insertion or within 72 hours after catheter removal. We used multivariable logistic regression to control for the catheter's position and dwell time as well as the infant's sex, gestational age, age at time of catheter insertion, birth weight, and weight at time of catheter insertion. RESULTS: We identified 135 cases of catheter-associated bloodstream infection. The mean catheter dwell time was 12.2 days (range, 0-113 days), and the mean time to bloodstream infection was 10.8 days (range, 1-57 days). An increase in catheter dwell time was associated with a lower risk of bloodstream infection (odds ratio, 0.975 [95% confidence interval, 0.954-0.996]; P = .02). CONCLUSION: No increased risk of catheter-associated bloodstream infection was observed with increased catheter dwell time. This may have been due to the infant's improved nutrition, decreased need for other invasive devices, and maturing skin and immune system as catheter dwell time increased.
OBJECTIVE: To estimate the risk of bloodstream infection associated with catheter dwell time in infants. DESIGN: Retrospective study. SETTING: Duke University Medical Center neonatal intensive care unit, an academic, level 3 nursery in Durham, North Carolina. METHODS: A case of catheter-associated bloodstream infection was defined as one that occurred in an infant whose culture-positive blood sample was collected more than 24 hours after catheter insertion or within 72 hours after catheter removal. We used multivariable logistic regression to control for the catheter's position and dwell time as well as the infant's sex, gestational age, age at time of catheter insertion, birth weight, and weight at time of catheter insertion. RESULTS: We identified 135 cases of catheter-associated bloodstream infection. The mean catheter dwell time was 12.2 days (range, 0-113 days), and the mean time to bloodstream infection was 10.8 days (range, 1-57 days). An increase in catheter dwell time was associated with a lower risk of bloodstream infection (odds ratio, 0.975 [95% confidence interval, 0.954-0.996]; P = .02). CONCLUSION: No increased risk of catheter-associated bloodstream infection was observed with increased catheter dwell time. This may have been due to the infant's improved nutrition, decreased need for other invasive devices, and maturing skin and immune system as catheter dwell time increased.
Authors: Naomi P O'Grady; Mary Alexander; E Patchen Dellinger; Julie L Gerberding; Stephen O Heard; Dennis G Maki; Henry Masur; Rita D McCormick; Leonard A Mermel; Michele L Pearson; Issam I Raad; Adrienne Randolph; Robert A Weinstein Journal: MMWR Recomm Rep Date: 2002-08-09
Authors: Barbara J Stoll; Nellie Hansen; Avroy A Fanaroff; Linda L Wright; Waldemar A Carlo; Richard A Ehrenkranz; James A Lemons; Edward F Donovan; Ann R Stark; Jon E Tyson; William Oh; Charles R Bauer; Sheldon B Korones; Seetha Shankaran; Abbot R Laptook; David K Stevenson; Lu-Ann Papile; W Kenneth Poole Journal: Pediatrics Date: 2002-08 Impact factor: 7.124
Authors: D K Cobb; K P High; R G Sawyer; C A Sable; R B Adams; D A Lindley; T L Pruett; K J Schwenzer; B M Farr Journal: N Engl J Med Date: 1992-10-08 Impact factor: 91.245
Authors: Reese Clark; Richard Powers; Robert White; Barry Bloom; Pablo Sanchez; Daniel K Benjamin Journal: J Perinatol Date: 2004-07 Impact factor: 2.521
Authors: Li-Yin Chien; Ying Macnab; Khalid Aziz; Wayne Andrews; Douglas D McMillan; Shoo K Lee Journal: Pediatr Infect Dis J Date: 2002-06 Impact factor: 2.129
Authors: Aaron M Milstone; Nicholas G Reich; Sonali Advani; Guoshu Yuan; Kristina Bryant; Susan E Coffin; W Charles Huskins; Robyn Livingston; Lisa Saiman; P Brian Smith; Xiaoyan Song Journal: Pediatrics Date: 2013-11-11 Impact factor: 7.124
Authors: Scott L Weiss; Mark J Peters; Waleed Alhazzani; Michael S D Agus; Heidi R Flori; David P Inwald; Simon Nadel; Luregn J Schlapbach; Robert C Tasker; Andrew C Argent; Joe Brierley; Joseph Carcillo; Enitan D Carrol; Christopher L Carroll; Ira M Cheifetz; Karen Choong; Jeffry J Cies; Andrea T Cruz; Daniele De Luca; Akash Deep; Saul N Faust; Claudio Flauzino De Oliveira; Mark W Hall; Paul Ishimine; Etienne Javouhey; Koen F M Joosten; Poonam Joshi; Oliver Karam; Martin C J Kneyber; Joris Lemson; Graeme MacLaren; Nilesh M Mehta; Morten Hylander Møller; Christopher J L Newth; Trung C Nguyen; Akira Nishisaki; Mark E Nunnally; Margaret M Parker; Raina M Paul; Adrienne G Randolph; Suchitra Ranjit; Lewis H Romer; Halden F Scott; Lyvonne N Tume; Judy T Verger; Eric A Williams; Joshua Wolf; Hector R Wong; Jerry J Zimmerman; Niranjan Kissoon; Pierre Tissieres Journal: Intensive Care Med Date: 2020-02 Impact factor: 17.440
Authors: Rachel G Greenberg; Keith M Cochran; P Brian Smith; Barbara S Edson; Joseph Schulman; Henry C Lee; Balaji Govindaswami; Alfonso Pantoja; Doug Hardy; John Curran; Della Lin; Sheree Kuo; Akihiko Noguchi; Patricia Ittmann; Scott Duncan; Munish Gupta; Alan Picarillo; Padmani Karna; Morris Cohen; Michael Giuliano; Sheri Carroll; Brandi Page; Judith Guzman-Cottrill; M Whit Walker; Jeff Garland; Janice K Ancona; Dan L Ellsbury; Matthew M Laughon; Martin J McCaffrey Journal: Pediatrics Date: 2015-11-16 Impact factor: 9.703