| Literature DB >> 18582053 |
Cheol Hong Cheon1, Hisashi Yamamoto.
Abstract
A highly reactive and robust chiral Brønsted acid catalyst, chiral N-triflyl thiophosphoramide, was developed. The first metal-free Brønsted acid catalyzed enantioselective protonation reaction of silyl enol ethers was demonstrated using this chiral Brønsted acid catalyst. The catalyst loading could be reduced to 0.05 mol % without any deleterious effect on the enantioselectivity.Entities:
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Year: 2008 PMID： 18582053 PMCID： PMC2559973 DOI： 10.1021/ja8041542
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419