PURPOSE: To compare the value of diffusion-weighted MRI (DWI), dynamic contrast-enhanced (DCE) MRI, and microbubble contrast-enhanced ultrasound (CEUS) for assessment of the thermal lesion created by interstitial microwave heating of the normal canine prostate. MATERIALS AND METHODS: A microwave antenna was inserted into each lobe of the prostate in seven dogs to induce coagulation necrosis. Immediately after therapy the lesion was assessed using CEUS, DCE-MRI, and DWI. The prostates were excised, photographed, and prepared for hematoxylin and eosin staining. Results from posttreatment MRI and ultrasound were compared to histology. RESULTS: The apparent diffusion coefficient (ADC) was slightly lowered within the thermal lesion but was drastically reduced in a ring-like region that corresponds to a grossly appearing red thermal damage zone immediately peripheral to the central coagulum. Both DCE-MRI and CEUS delineated a smaller area of vascular damage, for which the borders lie within the red zone. CONCLUSION: The red zone encompasses a range of vascular responses, including hyperemia and hemostasis, and is known to progress to necrosis and tissue nonviability. DWI clearly depicts this zone as a region of sharply reduced ADC, and may be better than contrast-enhanced imaging for accurate assessment of the eventual full extent of thermal damage. (c) 2008 Wiley-Liss, Inc.
PURPOSE: To compare the value of diffusion-weighted MRI (DWI), dynamic contrast-enhanced (DCE) MRI, and microbubble contrast-enhanced ultrasound (CEUS) for assessment of the thermal lesion created by interstitial microwave heating of the normal canine prostate. MATERIALS AND METHODS: A microwave antenna was inserted into each lobe of the prostate in seven dogs to induce coagulation necrosis. Immediately after therapy the lesion was assessed using CEUS, DCE-MRI, and DWI. The prostates were excised, photographed, and prepared for hematoxylin and eosin staining. Results from posttreatment MRI and ultrasound were compared to histology. RESULTS: The apparent diffusion coefficient (ADC) was slightly lowered within the thermal lesion but was drastically reduced in a ring-like region that corresponds to a grossly appearing red thermal damage zone immediately peripheral to the central coagulum. Both DCE-MRI and CEUS delineated a smaller area of vascular damage, for which the borders lie within the red zone. CONCLUSION: The red zone encompasses a range of vascular responses, including hyperemia and hemostasis, and is known to progress to necrosis and tissue nonviability. DWI clearly depicts this zone as a region of sharply reduced ADC, and may be better than contrast-enhanced imaging for accurate assessment of the eventual full extent of thermal damage. (c) 2008 Wiley-Liss, Inc.
Authors: Mostafa Atri; Mark R Gertner; Masoom A Haider; Robert A Weersink; John Trachtenberg Journal: Can Urol Assoc J Date: 2009-04 Impact factor: 1.862
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Authors: Steven P Allen; Francesco Prada; Zhiyuan Xu; Jeremy Gatesman; Xue Feng; Helen Sporkin; Yekaterina Gilbo; Sydney DeCleene; Kim Butts Pauly; Craig H Meyer Journal: Magn Reson Med Date: 2020-11-11 Impact factor: 3.737