OBJECTIVES: Depression has been associated with impaired neural processing of reward and punishment. However, to date, little is known regarding the relationship between depression and intertemporal choice (delay discounting) for gain and loss. This examination is potentially important for advances in neuroeconomics of intertemporal choice, because depression is associated with reduced serotonergic activities in the brain. DESIGN AND SETTING: We compared impulsivity and inconsistency in intertemporal choice for monetary gain and loss between depressive patients and healthy control subjects. METHODS: We conducted delay discounting tasks for gain and loss in depressed and healthy control subjects. We then quantified impulsivity and inconsistency in the delay discounting with parameters in the q-exponential discount function based on Tsallis' statistics. RESULTS: We observed that depressive patients were more impulsive and time-inconsistent in intertemporal choice action for gain and loss, in comparison to healthy controls. MAIN FINDINGS: Depressed patients were more irrational in temporal discounting. CONCLUSIONS: The usefulness of the q-exponential discount function for assessing the impaired decision-making by depressive patients was demonstrated. Furthermore, biophysical mechanisms underlying the altered intertemporal choice by depressive patients are discussed in relation to impaired serotonergic neural systems.
OBJECTIVES:Depression has been associated with impaired neural processing of reward and punishment. However, to date, little is known regarding the relationship between depression and intertemporal choice (delay discounting) for gain and loss. This examination is potentially important for advances in neuroeconomics of intertemporal choice, because depression is associated with reduced serotonergic activities in the brain. DESIGN AND SETTING: We compared impulsivity and inconsistency in intertemporal choice for monetary gain and loss between depressivepatients and healthy control subjects. METHODS: We conducted delay discounting tasks for gain and loss in depressed and healthy control subjects. We then quantified impulsivity and inconsistency in the delay discounting with parameters in the q-exponential discount function based on Tsallis' statistics. RESULTS: We observed that depressivepatients were more impulsive and time-inconsistent in intertemporal choice action for gain and loss, in comparison to healthy controls. MAIN FINDINGS:Depressedpatients were more irrational in temporal discounting. CONCLUSIONS: The usefulness of the q-exponential discount function for assessing the impaired decision-making by depressivepatients was demonstrated. Furthermore, biophysical mechanisms underlying the altered intertemporal choice by depressivepatients are discussed in relation to impaired serotonergic neural systems.
Authors: Andrzej Jakubczyk; Anna Klimkiewicz; Aleksandra Topolewska-Wochowska; Piotr Serafin; Joanna Sadowska-Mazuryk; Julia Pupek-Pyzioł; Kirk J Brower; Marcin Wojnar Journal: J Affect Disord Date: 2011-10-24 Impact factor: 4.839
Authors: Elizabeth A Olson; Roselinde H Kaiser; Diego A Pizzagalli; Scott L Rauch; Isabelle M Rosso Journal: Biol Psychiatry Cogn Neurosci Neuroimaging Date: 2017-11-16
Authors: George S Alexopoulos; Patrick J Raue; Faith Gunning; Dimitris N Kiosses; Dora Kanellopoulos; Cristina Pollari; Samprit Banerjee; Patricia A Arean Journal: Am J Geriatr Psychiatry Date: 2015-12-17 Impact factor: 4.105
Authors: Elske Vrieze; Diego A Pizzagalli; Koen Demyttenaere; Titia Hompes; Pascal Sienaert; Peter de Boer; Mark Schmidt; Stephan Claes Journal: Biol Psychiatry Date: 2012-12-08 Impact factor: 13.382