Literature DB >> 18580452

The cAMP/Epac1/Rap1 pathway in pancreatic carcinoma.

Richard Lorenz, Tamara Aleksic, Martin Wagner, Guido Adler, Christoph K Weber.   

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Year:  2008        PMID： 18580452     DOI： 10.1097/MPA.0b013e318160748f

Source DB:  PubMed          Journal:  Pancreas        ISSN： 0885-3177            Impact factor:   3.327


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  21 in total

1.  Role of exchange protein directly activated by cAMP (EPAC1) in breast cancer cell migration and apoptosis.

Authors:  Naveen Kumar; Sonal Gupta; Surbhi Dabral; Shailja Singh; Seema Sehrawat
Journal:  Mol Cell Biochem       Date:  2017-02-16       Impact factor: 3.396

Review 2.  Intracellular cAMP Sensor EPAC: Physiology, Pathophysiology, and Therapeutics Development.

Authors:  William G Robichaux; Xiaodong Cheng
Journal:  Physiol Rev       Date:  2018-04-01       Impact factor: 37.312

3.  Allosteric inhibition of Epac: computational modeling and experimental validation to identify allosteric sites and inhibitors.

Authors:  Loren M Brown; Kathleen E Rogers; Nakon Aroonsakool; J Andrew McCammon; Paul A Insel
Journal:  J Biol Chem       Date:  2014-09-02       Impact factor: 5.157

4.  Pharmacological inhibition and genetic knockdown of exchange protein directly activated by cAMP 1 reduce pancreatic cancer metastasis in vivo.

Authors:  Muayad Almahariq; Celia Chao; Fang C Mei; Mark R Hellmich; Igor Patrikeev; Massoud Motamedi; Xiaodong Cheng
Journal:  Mol Pharmacol       Date:  2014-11-10       Impact factor: 4.436

5.  Isoform-specific antagonists of exchange proteins directly activated by cAMP.

Authors:  Tamara Tsalkova; Fang C Mei; Sheng Li; Oleg G Chepurny; Colin A Leech; Tong Liu; George G Holz; Virgil L Woods; Xiaodong Cheng
Journal:  Proc Natl Acad Sci U S A       Date:  2012-10-22       Impact factor: 11.205

6.  Efficient Synthesis of ESI-09, A Novel Non-cyclic Nucleotide EPAC Antagonist.

Authors:  Haijun Chen; Chunyong Ding; Christopher Wild; Huiling Liu; Tianzhi Wang; Mark A White; Xiaodong Cheng; Jia Zhou
Journal:  Tetrahedron Lett       Date:  2013-03-20       Impact factor: 2.415

7.  A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and invasion.

Authors:  Muayad Almahariq; Tamara Tsalkova; Fang C Mei; Haijun Chen; Jia Zhou; Sarita K Sastry; Frank Schwede; Xiaodong Cheng
Journal:  Mol Pharmacol       Date:  2012-10-11       Impact factor: 4.436

Review 8.  EPAC proteins transduce diverse cellular actions of cAMP.

Authors:  Gillian Borland; Brian O Smith; Stephen J Yarwood
Journal:  Br J Pharmacol       Date:  2009-02-06       Impact factor: 8.739

Review 9.  The pleiotropic role of exchange protein directly activated by cAMP 1 (EPAC1) in cancer: implications for therapeutic intervention.

Authors:  Muayad Almahariq; Fang C Mei; Xiaodong Cheng
Journal:  Acta Biochim Biophys Sin (Shanghai)       Date:  2015-11-02       Impact factor: 3.848

10.  Epac1-induced cellular proliferation in prostate cancer cells is mediated by B-Raf/ERK and mTOR signaling cascades.

Authors:  Uma Kant Misra; Salvatore Vincent Pizzo
Journal:  J Cell Biochem       Date:  2009-11-01       Impact factor: 4.429
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