| Literature DB >> 18579435 |
Vanessa Siqueira Grazeffe1, Lenita de Freitas Tallarico, Alessandro de Sá Pinheiro, Toshie Kawano, Miriam Fussae Suzuki, Kayo Okazaki, Carlos Alberto de Bragança Pereira, Eliana Nakano.
Abstract
The single cell gel electrophoresis or the comet assay was established in the freshwater snail Biomphalaria glabrata. For detecting DNA damage in circulating hemocytes, adult snails were irradiated with single doses of 2.5, 5, 10 and 20 Gy of (60)Co gamma radiation. Genotoxic effect of ionizing radiation was detected at all doses as a dose-related increase in DNA migration. Comet assay in B. glabrata demonstrated to be a simple, fast and reliable tool in the evaluation of genotoxic effects of environmental mutagens.Entities:
Mesh：
Year: 2008 PMID： 18579435 DOI： 10.1016/j.mrgentox.2008.05.007
Source DB: PubMed Journal: Mutat Res ISSN： 0027-5107 Impact factor: 2.433