| Literature DB >> 18579372 |
Samir Ghosh1, Pallavi Tiwari, Shashi Pandey, Anup Kumar Misra, Vinita Chaturvedi, Anil Gaikwad, Shalini Bhatnagar, Sudhir Sinha.
Abstract
A series of glycosyl thioacetamide and glycosyl sulfonyl acetamide derivatives have been prepared following a convenient reaction protocol and evaluated for their antitubercular activity against Mycobacterium tuberculosis H(37)Rv. Amongst 32 compounds evaluated 3 compounds were effective in inhibiting mycobacterial growth at MIC of 6.25 microg/mL, 6 compounds at MIC of 3.125 microg/mL and 1 compound at MIC of 1.56 microg/mL. All active compounds were found nontoxic in Vero cell lines and mice bone marrow macrophages.Entities:
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Year: 2008 PMID： 18579372 DOI： 10.1016/j.bmcl.2008.06.004
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823