Literature DB >> 18579300

Edaravone, a free radical scavenger, ameliorates experimental autoimmune encephalomyelitis.

Masayuki Moriya1, Yuji Nakatsuji, Katsuichi Miyamoto, Tatsusada Okuno, Makoto Kinoshita, Atsushi Kumanogoh, Susumu Kusunoki, Saburo Sakoda.   

Abstract

Reactive oxygen species (ROS) are implicated in the pathogenesis of multiple sclerosis (MS) and its murine model experimental autoimmune encephalomyelitis (EAE). The effect of edaravone, a free radical scavenger, on EAE was investigated in this study. Treatment with edaravone significantly ameliorated the clinical severity of EAE, and a reduced infiltration of lymphocytes was observed based on a histological analysis. The expression of inducible NO synthase (iNOS) in the spinal cords appeared to be reduced by the treatment with edaravone and this effect was confirmed in vitro. A reduction of both the cellular infiltration and the expression of iNOS may therefore underlie the mechanisms of the beneficial effect of edaravone on EAE.

Entities:  

Mesh：

Substances：

Year:  2008        PMID： 18579300     DOI： 10.1016/j.neulet.2008.05.110

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  13 in total

1.  Microwave and magnetic (M(2) ) proteomics of the experimental autoimmune encephalomyelitis animal model of multiple sclerosis.

Authors:  Itay Raphael; Swetha Mahesula; Karan Kalsaria; Venkat Kotagiri; Anjali B Purkar; Manjushree Anjanappa; Darshit Shah; Vidya Pericherla; Yeshwant Lal Avinash Jadhav; Rekha Raghunathan; Michael Vaynberg; David Noriega; Nazul H Grimaldo; Carola Wenk; Jonathan A L Gelfond; Thomas G Forsthuber; William E Haskins
Journal:  Electrophoresis       Date:  2012-12       Impact factor: 3.535

2.  Edaravone Inhibits the Production of Reactive Oxygen Species in Phagocytosis- and PKC-Stimulated Granulocytes from Multiple Sclerosis Patients Edaravone Modulate Oxidative Stress in Multiple Sclerosis.

Authors:  Pedro Henrique Villar-Delfino; Nathália Augusta Oliveira Gomes; Paulo Pereira Christo; José Augusto Nogueira-Machado; Caroline Maria Oliveira Volpe
Journal:  J Cent Nerv Syst Dis       Date:  2022-05-16

3.  Calcium intervention ameliorates experimental model of multiple sclerosis.

Authors:  Dariush Haghmorad; Mohammad B Mahmoudi; Mahmoud Mahmoudi; Shahrzad Z T Rab; Maryam Rastin; Hamid Shegarfi; Gholamreza Azizi; Abbas Mirshafiey
Journal:  Oman Med J       Date:  2014-05

4.  TRPM2 Exacerbates Central Nervous System Inflammation in Experimental Autoimmune Encephalomyelitis by Increasing Production of CXCL2 Chemokines.

Authors:  Masato Tsutsui; Ryo Hirase; Sakie Miyamura; Kazuki Nagayasu; Takayuki Nakagawa; Yasuo Mori; Hisashi Shirakawa; Shuji Kaneko
Journal:  J Neurosci       Date:  2018-09-10       Impact factor: 6.167

Review 5.  New insights in the mechanisms of impaired redox signaling and its interplay with inflammation and immunity in multiple sclerosis.

Authors:  D Michaličková; M Šíma; O Slanař
Journal:  Physiol Res       Date:  2019-12-19       Impact factor: 1.881

6.  Edaravone attenuates disease severity of experimental auto-immune encephalomyelitis and increases gene expression of Nrf2 and HO-1.

Authors:  Danica Michaličková; Hatice Kübra Öztürk; J Hroudová; M Ľupták; T Kučera; T Hrnčíř; N Kutinová Canová; M Šíma; O Slanař
Journal:  Physiol Res       Date:  2022-01-19       Impact factor: 1.881

7.  Phase I clinical study of edaravone in healthy Chinese volunteers: safety and pharmacokinetics of single or multiple intravenous infusions.

Authors:  Hao Li; Kun Xu; Yongqing Wang; Hongwen Zhang; Tianping Li; Ling Meng; Xiaojian Gong; Haibo Zhang; Ning Ou; Jinman Ruan
Journal:  Drugs R D       Date:  2012-06-01

8.  A pain-mediated neural signal induces relapse in murine autoimmune encephalomyelitis, a multiple sclerosis model.

Authors:  Yasunobu Arima; Daisuke Kamimura; Toru Atsumi; Masaya Harada; Tadafumi Kawamoto; Naoki Nishikawa; Andrea Stofkova; Takuto Ohki; Kotaro Higuchi; Yuji Morimoto; Peter Wieghofer; Yuka Okada; Yuki Mori; Saburo Sakoda; Shizuya Saika; Yoshichika Yoshioka; Issei Komuro; Toshihide Yamashita; Toshio Hirano; Marco Prinz; Masaaki Murakami
Journal:  Elife       Date:  2015-08-11       Impact factor: 8.140

9.  Xanthine oxidase mediates axonal and myelin loss in a murine model of multiple sclerosis.

Authors:  Josephe Archie Honorat; Makoto Kinoshita; Tatsusada Okuno; Kazushiro Takata; Toru Koda; Satoru Tada; Takashi Shirakura; Harutoshi Fujimura; Hideki Mochizuki; Saburo Sakoda; Yuji Nakatsuji
Journal:  PLoS One       Date:  2013-08-08       Impact factor: 3.240

10.  Hydroxycitric acid ameliorates inflammation and oxidative stress in mouse models of multiple sclerosis.

Authors:  Mahdi Goudarzvand; Sanaz Afraei; Somaye Yaslianifard; Saleh Ghiasy; Ghazal Sadri; Mustafa Kalvandi; Tina Alinia; Ali Mohebbi; Reza Yazdani; Shahin Khadem Azarian; Abbas Mirshafiey; Gholamreza Azizi
Journal:  Neural Regen Res       Date:  2016-10       Impact factor: 5.135
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.