| Literature DB >> 18577375 |
Yasuka Isa1, Yuri Miyakawa, Masayoshi Yanagisawa, Tsuyoshi Goto, Min-Sook Kang, Teruo Kawada, Yasujiro Morimitsu, Kikue Kubota, Takanori Tsuda.
Abstract
In this study, we demonstrated that the two ginger-derived components have a potent and unique pharmacological function in 3T3-L1 adipocytes via different mechanisms. Both pretreatment of 6-shogaol (6S) and 6-gingerol (6G) significantly inhibited the tumor necrosis factor-alpha (TNF-alpha) mediated downregulation of the adiponectin expression in 3T3-L1 adipocytes. Our study demonstrate that (1) 6S functions as a PPARgamma agonist with its inhibitory mechanism due to the PPARgamma transactivation, and (2) 6G is not a PPARgamma agonist, but it is an effective inhibitor of TNF-alpha induced c-Jun-NH(2)-terminal kinase signaling activation and thus, its inhibitory mechanism is due to this inhibitory effect.Entities:
Mesh：
Substances：
Year: 2008 PMID： 18577375 DOI： 10.1016/j.bbrc.2008.06.046
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575