Literature DB >> 18575924

Treatment wish of individuals with known and unknown restless legs syndrome in the community.

Svenja Happe1, Mechthild Vennemann, Stefan Evers, Klaus Berger.   

Abstract

STUDY
OBJECTIVES: Restless legs syndrome (RLS) is a frequent sleep disorder with a prevalence of 5% to 15% in Caucasian populations. Dopaminergic treatment is known to reduce sensorimotor RLS symptoms and is approved for RLS, but not all patients ask for treatment. About 2% to 3% of patients presenting to a primary care physician require RLS-specific treatment. The overall treatment preference of RLS sufferers, however, is still unknown. The aim of this study was to assess the prevalence and treatment preference in patients with previously diagnosed and those with yet undiagnosed RLS in a population-based survey in Germany. DESIGN AND
SETTING: Cross-sectional health survey with face-to-face interviews with 1312 participants in the Dortmund Health Study. RLS was assessed with standardized, validated questions addressing the four minimal diagnostic criteria for RLS defined by the International Restless Legs Syndrome Study Group. PARTICIPANTS: Participants were aged 25 to 75 years and were randomly selected from the city register.
RESULTS: The overall prevalence of individuals with a known doctor diagnosis of RLS was 2.3%. In addition, 6.5% fulfilled the four minimal criteria but did not know about this diagnosis yielding an overall prevalence of 8.8%. Prevalence was higher in women (10.2%) and German descendents (9.2%) compared to men (7.1%) and migrants (6.7%). Almost 60% of all RLS cases reported symptoms at least once a week. 33.3% of cases with a known RLS diagnosis and 14.1 % with an unknown diagnosis had an RLS treatment wish. The latter is determined by knowledge of the diagnosis, daily symptoms, diabetes and sleep disturbance.
CONCLUSION: About every fourth RLS case knows about the diagnosis and overall every fifth RLS case wishes medication to effectively reduce symptoms, corresponding to 1.6% of the whole study population.

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Mesh:

Year:  2008        PMID: 18575924     DOI: 10.1007/s00415-008-0922-7

Source DB:  PubMed          Journal:  J Neurol        ISSN: 0340-5354            Impact factor:   4.849


  11 in total

1.  Impact, diagnosis and treatment of restless legs syndrome (RLS) in a primary care population: the REST (RLS epidemiology, symptoms, and treatment) primary care study.

Authors:  Wayne Hening; Arthur S Walters; Richard P Allen; Jacques Montplaisir; Andrew Myers; Luigi Ferini-Strambi
Journal:  Sleep Med       Date:  2004-05       Impact factor: 3.492

Review 2.  Less is more: pathophysiology of dopaminergic-therapy-related augmentation in restless legs syndrome.

Authors:  Walter Paulus; Claudia Trenkwalder
Journal:  Lancet Neurol       Date:  2006-10       Impact factor: 44.182

3.  Restless legs syndrome: a community-based study of prevalence, severity, and risk factors.

Authors:  B Högl; S Kiechl; J Willeit; M Saletu; B Frauscher; K Seppi; J Müller; G Rungger; A Gasperi; G Wenning; W Poewe
Journal:  Neurology       Date:  2005-06-14       Impact factor: 9.910

Review 4.  Epidemiology of restless legs syndrome: the current status.

Authors:  Diego Garcia-Borreguero; Renata Egatz; Juliane Winkelmann; Klaus Berger
Journal:  Sleep Med Rev       Date:  2006-06       Impact factor: 11.609

5.  Prevalence and risk factors of RLS in an elderly population: the MEMO study. Memory and Morbidity in Augsburg Elderly.

Authors:  A J Rothdach; C Trenkwalder; J Haberstock; U Keil; K Berger
Journal:  Neurology       Date:  2000-03-14       Impact factor: 9.910

Review 6.  Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health.

Authors:  Richard P Allen; Daniel Picchietti; Wayne A Hening; Claudia Trenkwalder; Arthur S Walters; Jacques Montplaisi
Journal:  Sleep Med       Date:  2003-03       Impact factor: 3.492

7.  Iron metabolism and the risk of restless legs syndrome in an elderly general population--the MEMO-Study.

Authors:  Klaus Berger; Arnold von Eckardstein; Claudia Trenkwalder; Andreas Rothdach; Ralf Junker; Stephan Karl Weiland
Journal:  J Neurol       Date:  2002-09       Impact factor: 4.849

8.  Unexpectedly low prevalence and unusual characteristics of RLS in Mersin, Turkey.

Authors:  S Sevim; O Dogu; H Camdeviren; R Bugdayci; T Sasmaz; H Kaleagasi; M Aral; I Helvaci
Journal:  Neurology       Date:  2003-12-09       Impact factor: 9.910

Review 9.  Toward a better definition of the restless legs syndrome. The International Restless Legs Syndrome Study Group.

Authors:  A S Walters
Journal:  Mov Disord       Date:  1995-09       Impact factor: 10.338

10.  Sex and the risk of restless legs syndrome in the general population.

Authors:  Klaus Berger; Jan Luedemann; Claudia Trenkwalder; Ulrich John; Christof Kessler
Journal:  Arch Intern Med       Date:  2004-01-26
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  18 in total

Review 1.  Restless legs syndrome: a comprehensive overview on its epidemiology, risk factors, and treatment.

Authors:  Paul Yeh; Arthur S Walters; John W Tsuang
Journal:  Sleep Breath       Date:  2011-10-26       Impact factor: 2.816

Review 2.  Prevalence of restless legs syndrome in North American and Western European populations: a systematic review.

Authors:  Kim E Innes; Terry Kit Selfe; Parul Agarwal
Journal:  Sleep Med       Date:  2011-07-12       Impact factor: 3.492

3.  Recent advances in the diagnosis, genetics and treatment of restless legs syndrome.

Authors:  Claudia Trenkwalder; Birgit Högl; Juliane Winkelmann
Journal:  J Neurol       Date:  2009-04-27       Impact factor: 4.849

4.  Health economic burden of patients with restless legs syndrome in a German ambulatory setting.

Authors:  Richard Dodel; Svenja Happe; Ines Peglau; Geert Mayer; Jürgen Wasem; Jens-Peter Reese; Guido Giani; Max Geraedts; Claudia Trenkwalder; Wolfgang H Oertel; Karin Stiasny-Kolster
Journal:  Pharmacoeconomics       Date:  2010       Impact factor: 4.981

5.  Sleep-Related Disorders in Neurology and Psychiatry.

Authors:  Jan Rémi; Thomas Pollmächer; Kai Spiegelhalder; Claudia Trenkwalder; Peter Young
Journal:  Dtsch Arztebl Int       Date:  2019-10-11       Impact factor: 5.594

6.  Vascular risk factors, cardiovascular disease, and restless legs syndrome in men.

Authors:  Anke C Winter; Klaus Berger; Robert J Glynn; Julie E Buring; J Michael Gaziano; Markus Schürks; Tobias Kurth
Journal:  Am J Med       Date:  2013-03       Impact factor: 4.965

7.  [Practical guidelines for diagnosis and therapy of restless legs syndrome].

Authors:  M Krenzer; W Oertel; C Trenkwalder
Journal:  Nervenarzt       Date:  2014-01       Impact factor: 1.214

8.  Lack of Association between Genetic Risk Loci for Restless Legs Syndrome and Multimorbidity.

Authors:  András Szentkirályi; Henry Völzke; Wolfgang Hoffmann; Julianne Winkelmann; Klaus Berger
Journal:  Sleep       Date:  2016-01-01       Impact factor: 5.849

Review 9.  [Restless legs syndrome and nocturnal leg pain : Differential diagnosis and treatment].

Authors:  M Hornyak; K Stiasny-Kolster; S Evers; S Happe
Journal:  Schmerz       Date:  2011-09       Impact factor: 1.107

10.  Genetic TPH2 variants and the susceptibility for migraine: association of a TPH2 haplotype with migraine without aura.

Authors:  Alexander Jung; Andreas Huge; Gregor Kuhlenbäumer; Steffi Kempt; Tanja Seehafer; Stefan Evers; Klaus Berger; Martin Marziniak
Journal:  J Neural Transm (Vienna)       Date:  2010-08-26       Impact factor: 3.575

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