Literature DB >> 18575824

Bcl-2 antisense oligonucleotide inhibits the proliferation of childhood leukemia/lymphoma cells of the B-cell lineage.

István Szegedi1, Klára Katona, András Horváth, Anna Molnár, János Aradi, Csongor Kiss.   

Abstract

An 18-mer phosphorothioate bcl-2 antisense oligonucleotide (ASO) inhibited colony formation of three B-cell leukemia/lymphoma cell lines in a dose dependent manner in the range of 0.125-0.5 micromol/l. The scrambled cogener had no detectable effect. A decrease in BCL-2 protein and apoptotic DNA fragmentation was detected in the studied cell lines and primary blast cells of two children with acute lymphoblastic leukemia. Neither BCL-2 protein level, nor DNA integrity was affected by the scrambled control indicating the specific effect ASO. As far as we know, this is the first report on the effects of bcl-2 ASO on childhood leukemia/lymphoma cell samples.

Entities:  

Mesh：

Substances：

Year:  2008        PMID： 18575824     DOI： 10.1007/s12253-008-9076-2

Source DB:  PubMed          Journal:  Pathol Oncol Res        ISSN： 1219-4956            Impact factor:   3.201


  20 in total

1.  Cellular drug resistance profiles in childhood acute myeloid leukemia: differences between FAB types and comparison with acute lymphoblastic leukemia.

Authors:  C M Zwaan; G J Kaspers; R Pieters; N L Ramakers-Van Woerden; M L den Boer; R Wünsche; M M Rottier; K Hählen; E R van Wering; G E Janka-Schaub; U Creutzig; A J Veerman
Journal:  Blood       Date:  2000-10-15       Impact factor: 22.113

2.  Advantages of sodium perchlorate solution as mobile phase for purification of synthetic oligonucleotides by anion exchange chromatography.

Authors:  András Horváth; Janos Aradi
Journal:  Anal Biochem       Date:  2005-03-15       Impact factor: 3.365

3.  Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c.

Authors:  X Liu; C N Kim; J Yang; R Jemmerson; X Wang
Journal:  Cell       Date:  1996-07-12       Impact factor: 41.582

4.  Growth inhibitory effect of green tea extract in Ehrlich ascites tumor cells involves cytochrome c release and caspase activation.

Authors:  D O Kennedy; A Kojima; Y Yano; T Hasuma; S Otani; I Matsui-Yuasa
Journal:  Cancer Lett       Date:  2001-05-10       Impact factor: 8.679

5.  B-cell maturation stages of Burkitt's lymphoma cell lines according to Epstein-Barr virus status and type of chromosome translocation.

Authors:  J H Cohen; J P Revillard; J P Magaud; G Lenoir; M Vuillaume; A M Manel; C Vincent; P A Bryon
Journal:  J Natl Cancer Inst       Date:  1987-02       Impact factor: 13.506

6.  Effect of myelopoietic and pleiotropic cytokines on colony formation by blast cells of children with acute lymphoblastic leukemia.

Authors:  I Benko; P Kovács; I Szegedi; A Megyeri; A Kiss; E Balogh; E Oláh; J Kappelmayer; C Kiss
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2001-05       Impact factor: 3.000

Review 7.  Oblimersen: Augmerosen, BCL-2 antisense oligonucleotide - Genta, G 3139, GC 3139, oblimersen sodium.

Authors: 
Journal:  Drugs R D       Date:  2007

8.  Modulation of malignant B cell activation and apoptosis by bcl-2 antisense ODN and immunostimulatory CpG ODN.

Authors:  B Jahrsdörfer; R Jox; L Mühlenhoff; K Tschoep; A Krug; S Rothenfusser; G Meinhardt; B Emmerich; S Endres; G Hartmann
Journal:  J Leukoc Biol       Date:  2002-07       Impact factor: 4.962

9.  Effects of BCL-2 antisense oligodeoxynucleotides on in vitro proliferation and survival of normal marrow progenitors and leukemic cells.

Authors:  L Campos; O Sabido; J P Rouault; D Guyotat
Journal:  Blood       Date:  1994-07-15       Impact factor: 22.113

10.  Lytic growth of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in culture.

Authors:  R Renne; W Zhong; B Herndier; M McGrath; N Abbey; D Kedes; D Ganem
Journal:  Nat Med       Date:  1996-03       Impact factor: 53.440
View more
  1 in total

Review 1.  Targeting paediatric acute lymphoblastic leukaemia: novel therapies currently in development.

Authors:  Alisa B Lee-Sherick; Rachel M A Linger; Lia Gore; Amy K Keating; Douglas K Graham
Journal:  Br J Haematol       Date:  2010-08-31       Impact factor: 6.998
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.