BACKGROUND: Nasal Polyposis (NP) is defined as a chronic inflammatory disease of sinonasal mucosa leading to diffuse formation of benign polyps. Although family histories are frequently suggested in medical literature, no specific study focused on this point has been reported. The purpose of this study is to determine whether a hereditary factor could be implied for NP in a family where several members were affected. We included 99 members of this family. METHODS: All patients were assessed for conditions known to be associated with the development or presence of NP. Concerning NP, patients were screened with a validated questionnaire and selected patients had a medical examination by an Ear, Nose and Throat practitioner. RESULTS: Thirteen patients had a personal history of NP without asthma, aspirin intolerance, Churg Strauss syndrome, cystic fibrosis, Young's syndrome, bare lymphocyte syndrome, or primary ciliary dyskinesia. Within this family, 19.7% of those older than 17 years were affected by NP, as compared with the national French prevalence of 2.1%. CONCLUSIONS: Regarding the pedigree, we discuss different modes of inheritance. The presence of consanguineous unions in this family suggests the possibility of a common ancestor and thus a recessive autosomal mode of inheritance.
BACKGROUND:Nasal Polyposis (NP) is defined as a chronic inflammatory disease of sinonasal mucosa leading to diffuse formation of benign polyps. Although family histories are frequently suggested in medical literature, no specific study focused on this point has been reported. The purpose of this study is to determine whether a hereditary factor could be implied for NP in a family where several members were affected. We included 99 members of this family. METHODS: All patients were assessed for conditions known to be associated with the development or presence of NP. Concerning NP, patients were screened with a validated questionnaire and selected patients had a medical examination by an Ear, Nose and Throat practitioner. RESULTS: Thirteen patients had a personal history of NP without asthma, aspirin intolerance, Churg Strauss syndrome, cystic fibrosis, Young's syndrome, bare lymphocyte syndrome, or primary ciliary dyskinesia. Within this family, 19.7% of those older than 17 years were affected by NP, as compared with the national French prevalence of 2.1%. CONCLUSIONS: Regarding the pedigree, we discuss different modes of inheritance. The presence of consanguineous unions in this family suggests the possibility of a common ancestor and thus a recessive autosomal mode of inheritance.
Authors: Joy Hsu; Pedro C Avila; Robert C Kern; M Geoffrey Hayes; Robert P Schleimer; Jayant M Pinto Journal: J Allergy Clin Immunol Date: 2013-04 Impact factor: 10.793
Authors: Ignacio Dávila; Carmen Rondón; Ana Navarro; Encarnación Antón; Carlos Colás; María Teresa Dordal; María Dolores Ibáñez; Beatriz Fernández-Parra; Magdalena Lluch-Bernal; Víctor Matheu; Javier Montoro; María Cesárea Sánchez; Antonio Valero Journal: Am J Rhinol Allergy Date: 2012 Sep-Oct Impact factor: 2.467
Authors: Frédéric Heymans; Adrien Fischer; Nicholas W Stow; Myriam Girard; Zacharias Vourexakis; Antoine Des Courtis; Gesuele Renzi; Elzbieta Huggler; Stefan Vlaminck; Pierre Bonfils; Ranko Mladina; Valerie Lund; Jacques Schrenzel; Patrice François; Jean Silvain Lacroix Journal: PLoS One Date: 2010-03-05 Impact factor: 3.240
Authors: Nithin D Adappa; Zi Zhang; James N Palmer; David W Kennedy; Laurel Doghramji; Anna Lysenko; Danielle R Reed; Thomas Scott; Nina W Zhao; David Owens; Robert J Lee; Noam A Cohen Journal: Int Forum Allergy Rhinol Date: 2013-12-02 Impact factor: 3.858
Authors: Boris Jelavic; Josipa Marković; Sanja Klarić; Marko Martinac; Sanja Selak; Tomislav Baudoin Journal: Turk Arch Otorhinolaryngol Date: 2018-03-01
Authors: Michael T Purkey; Jin Li; Frank Mentch; Struan F A Grant; Martin Desrosiers; Hakon Hakonarson; Elina Toskala Journal: PLoS One Date: 2014-03-03 Impact factor: 3.240