Literature DB >> 18574498

Actions of human telomerase beyond telomeres.

Yusheng Cong1, Jerry W Shay.   

Abstract

Telomerase has fundamental roles in bypassing cellular aging and in cancer progression by maintaining telomere homeostasis and integrity. However, recent studies have led some investigators to suggest novel biochemical properties of telomerase in several essential cell signaling pathways without apparent involvement of its well established function in telomere maintenance. These observations may further enhance our understanding of the molecular actions of telomerase in aging and cancer. This review will provide an update on the extracurricular activities of telomerase in apoptosis, DNA repair, stem cell function, and in the regulation of gene expression.

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Year:  2008        PMID： 18574498     DOI： 10.1038/cr.2008.74

Source DB:  PubMed          Journal:  Cell Res        ISSN： 1001-0602            Impact factor:   25.617


  84 in total

1.  Characterization and fate of telomerase-expressing epithelia during kidney repair.

Authors:  Jie Song; Suzanne Czerniak; Teresa Wang; Wendy Ying; Diana L Carlone; David T Breault; Benjamin D Humphreys
Journal:  J Am Soc Nephrol       Date:  2011-10-21       Impact factor: 10.121

2.  Separation of telomerase functions by reverse genetics.

Authors:  Shibani Mukherjee; Eduardo J Firpo; Yang Wang; James M Roberts
Journal:  Proc Natl Acad Sci U S A       Date:  2011-09-26       Impact factor: 11.205

3.  Role of progerin-induced telomere dysfunction in HGPS premature cellular senescence.

Authors:  Erica K Benson; Sam W Lee; Stuart A Aaronson
Journal:  J Cell Sci       Date:  2010-07-06       Impact factor: 5.285

4.  Excitotoxic and Radiation Stress Increase TERT Levels in the Mitochondria and Cytosol of Cerebellar Purkinje Neurons.

Authors:  Erez Eitan; Carmel Braverman; Ailone Tichon; Daniel Gitler; Emmette R Hutchison; Mark P Mattson; Esther Priel
Journal:  Cerebellum       Date:  2016-08       Impact factor: 3.847

Review 5.  The role of telomeres and telomerase reverse transcriptase isoforms in pluripotency induction and maintenance.

Authors:  Jonathan H Teichroeb; Joohwan Kim; Dean H Betts
Journal:  RNA Biol       Date:  2016-01-19       Impact factor: 4.652

6.  Telomeres and telomerase: from discovery to clinical trials.

Authors:  David R Corey
Journal:  Chem Biol       Date:  2009-12-24

Review 7.  Telomeric and extra-telomeric roles for telomerase and the telomere-binding proteins.

Authors:  Paula Martínez; María A Blasco
Journal:  Nat Rev Cancer       Date:  2011-03       Impact factor: 60.716

8.  Lung alveolar integrity is compromised by telomere shortening in telomerase-null mice.

Authors:  Jooeun Lee; Raghava Reddy; Lora Barsky; Jessica Scholes; Hui Chen; Wei Shi; Barbara Driscoll
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2008-10-24       Impact factor: 5.464

9.  Alternatively spliced telomerase reverse transcriptase variants lacking telomerase activity stimulate cell proliferation.

Authors:  Radmila Hrdlicková; Jirí Nehyba; Henry R Bose
Journal:  Mol Cell Biol       Date:  2012-08-20       Impact factor: 4.272

10.  Spaceflight effects on T lymphocyte distribution, function and gene expression.

Authors:  Daila S Gridley; James M Slater; Xian Luo-Owen; Asma Rizvi; Stephen K Chapes; Louis S Stodieck; Virginia L Ferguson; Michael J Pecaut
Journal:  J Appl Physiol (1985)       Date:  2008-11-06
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