| Literature DB >> 18573279 |
Debra C Quenelle1, Deborah J Collins, Terri L Rice, Mark N Prichard, Dante J Marciani, Earl R Kern.
Abstract
These studies were performed to determine the effect of AD-472, an attenuated human herpes simplex virus (HSV) type 2 or HSV-2 glycoprotein D (gD) when combined with an adjuvant, GPI-0100, a semi-synthetic Quillaja Saponin analog in a genital HSV-2 infection in guinea pigs. While animals immunized with either vaccine had reduced clinical disease, GPI-0100 only improved the efficacy of gD and did not affect the efficacy of the live vaccine. Neither vaccine had any therapeutic effect if administered 24 h after viral infection.Entities:
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Year: 2008 PMID： 18573279 PMCID： PMC3773812 DOI： 10.1016/j.antiviral.2008.05.011
Source DB: PubMed Journal: Antiviral Res ISSN： 0166-3542 Impact factor: 5.970