Literature DB >> 18572947

An efficient asymmetric synthesis of manzacidin C.

Kristy Tran1, Pamela J Lombardi, James L Leighton.   

Abstract

A brief synthesis of manzacidin C based on a chiral silane-promoted diastereo- and enatioselective acylhydrazone-alkene [3 + 2] cycloaddition reaction has been achieved. This synthesis is the first synthesis of any of the manzacidins wherein the C(4) and C(6) stereocenters are established in a single highly stereoselective step.

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Year:  2008        PMID： 18572947     DOI： 10.1021/ol8011869

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  5 in total

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Authors:  Yuji Nakano; Kyle F Biegasiewicz; Todd K Hyster
Journal:  Curr Opin Chem Biol       Date:  2018-09-27       Impact factor: 8.822

Review 2.  Enzymatic CH functionalizations for natural product synthesis.

Authors:  Fuzhuo Li; Xiao Zhang; Hans Renata
Journal:  Curr Opin Chem Biol       Date:  2018-09-27       Impact factor: 8.822

Review 3.  Synthesis of Non-Racemic Pyrazolines and Pyrazolidines by [3+2] Cycloadditions of Azomethine Imines.

Authors:  Franc Požgan; Hamad Al Mamari; Uroš Grošelj; Jurij Svete; Bogdan Štefane
Journal:  Molecules       Date:  2017-12-21       Impact factor: 4.411

4.  Organocatalytic cascade aza-Michael/hemiacetal reaction between disubstituted hydrazines and α,β-unsaturated aldehydes: Highly diastereo- and enantioselective synthesis of pyrazolidine derivatives.

Authors:  Zhi-Cong Geng; Jian Chen; Ning Li; Xiao-Fei Huang; Yong Zhang; Ya-Wen Zhang; Xing-Wang Wang
Journal:  Beilstein J Org Chem       Date:  2012-10-09       Impact factor: 2.883

5.  Modular synthesis of the pyrimidine core of the manzacidins by divergent Tsuji-Trost coupling.

Authors:  Sebastian Bretzke; Stephan Scheeff; Felicitas Vollmeyer; Friederike Eberhagen; Frank Rominger; Dirk Menche
Journal:  Beilstein J Org Chem       Date:  2016-06-02       Impact factor: 2.883
  5 in total

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