Literature DB >> 18572056

You're too old for that.

Vinay A Shah1, Sandeep Randhawa, Thomas Mizen, Andrew G Lee, Rod Foroozan.   

Abstract

Leber hereditary optic neuropathy (LHON) produces a subacute and typically bilateral but sequential optic neuropathy. LHON is a mitochondrial disease and the most common mutations are at positions 11778, 14484 and 3460. LHON typically presents in young (age 20-40), healthy men but may occur in either sex and at any age. We report a case of LHON in a 72-year-old man and we emphasize the importance of testing for LHON in all cases of unexplained bilateral and sequential optic neuropathy with a ceco-central or central scotoma.

Entities:  

Mesh：

Substances：

Year:  2008        PMID： 18572056     DOI： 10.1016/j.survophthal.2008.04.003

Source DB:  PubMed          Journal:  Surv Ophthalmol        ISSN： 0039-6257            Impact factor:   6.048


  5 in total

1.  Parsing the differences in affected with LHON: genetic versus environmental triggers of disease conversion.

Authors:  Valerio Carelli; Pio d'Adamo; Maria Lucia Valentino; Chiara La Morgia; Fred N Ross-Cisneros; Leonardo Caporali; Alessandra Maresca; Paola Loguercio Polosa; Piero Barboni; Annamaria De Negri; Federico Sadun; Rustum Karanjia; Solange R Salomao; Adriana Berezovsky; Filipe Chicani; Milton Moraes; Milton Moraes Filho; Rubens Belfort; Alfredo A Sadun
Journal:  Brain       Date:  2015-12-10       Impact factor: 13.501

Review 2.  Mitochondrial optic neuropathies - disease mechanisms and therapeutic strategies.

Authors:  Patrick Yu-Wai-Man; Philip G Griffiths; Patrick F Chinnery
Journal:  Prog Retin Eye Res       Date:  2010-11-26       Impact factor: 21.198

3.  Late-onset Leber hereditary optic neuropathy mimicking Susac's syndrome.

Authors:  Stefano Zoccolella; Vittoria Petruzzella; Francesco Prascina; Lucia Artuso; Francesca Pacillo; Rosa Dell'Aglio; Carlo Avolio; Nicola Delle Noci; Marcella Attimonelli; Luigi Maria Specchio
Journal:  J Neurol       Date:  2010-07-15       Impact factor: 4.849

4.  Leber's hereditary optic neuropathy with late disease onset: clinical and molecular characteristics of 20 patients.

Authors:  Konstantin Dimitriadis; Miriam Leonhardt; Patrick Yu-Wai-Man; Matthew Anthony Kirkman; Alex Korsten; Irenaeus F De Coo; Patrick Francis Chinnery; Thomas Klopstock
Journal:  Orphanet J Rare Dis       Date:  2014-10-23       Impact factor: 4.123

5.  Leber Hereditary Optic Neuropathy Associated with Bilateral Macular Holes.

Authors:  Yoshiaki Shimada; Masayuki Horiguchi
Journal:  Neuroophthalmology       Date:  2016-03-09
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.