| Literature DB >> 18571836 |
Ling Qiao1, Zhi-Li Xu, Tie-Jun Zhao, Li-Hong Ye, Xiao-Dong Zhang.
Abstract
We determined the molecular mechanism of inhibitory effect of human mesenchymal stem cells (hMSCs) on the growth of human MCF-7 breast cancer cells. Our finding showed that beta-catenin was down-regulated in MCF-7 cells by conditioned media from Z3 hMSCs, and the expression level of dickkopf-1 (Dkk-1) was higher in Z3 cells than that in MCF-7 cells. Neutralization of Dkk-1 and small interference RNA targeting Dkk-1 mRNA in Z3 cells attenuated the inhibitory effect of Z3 cells on MCF-7 cells. Overexpression of Dkk-1 in Z3 cells enhanced the inhibition. Therefore, Dkk-1 secreted by Z3 cells involves the inhibition via the Wnt pathway.Entities:
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Year: 2008 PMID： 18571836 DOI： 10.1016/j.canlet.2008.04.032
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679