Literature DB >> 18571481

Determination of d-limonene in adipose tissue by gas chromatography-mass spectrometry.

Jessica A Miller1, Iman A Hakim, Cynthia Thomson, Patricia Thompson, H-H Sherry Chow.   

Abstract

We developed a novel method for analyzing d-limonene levels in adipose tissue. Fat samples were subjected to saponification followed by solvent extraction. d-Limonene in the sample extract was analyzed using gas chromatography-mass spectrometry (GC-MS) with selected ion monitoring. Linear calibration curves were established over the mass range of 79.0-2529 ng d-limonene per 0.1g of adipose tissue. Satisfactory within-day precision (R.S.D. 6.7-9.6%) and accuracy (%difference of -2.7 to 3.8%) and between-day precision (R.S.D. 6.0-10.7%) and accuracy (%difference of 1.8-2.6%) were achieved. The assay was successfully applied to human fat biopsy samples from a d-limonene feeding trial.

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Year:  2008        PMID： 18571481      PMCID： PMC2505176          DOI： 10.1016/j.jchromb.2008.06.002

Source DB:  PubMed          Journal:  J Chromatogr B Analyt Technol Biomed Life Sci        ISSN： 1570-0232            Impact factor:   3.205


  19 in total

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5.  Inhibition of protein prenylation by metabolites of limonene.

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  4 in total

1.  Adipose tissue accumulation of d-limonene with the consumption of a lemonade preparation rich in d-limonene content.

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Journal:  Nutr Cancer       Date:  2010       Impact factor: 2.900

2.  Safety and Feasibility of Topical Application of Limonene as a Massage Oil to the Breast.

Authors:  Jessica A Miller; Patricia A Thompson; Iman A Hakim; Ana Maria Lopez; Cynthia A Thomson; Wade Chew; Chiu-Hsieh Hsu; H-H Sherry Chow
Journal:  J Cancer Ther       Date:  2012-10

3.  Human breast tissue disposition and bioactivity of limonene in women with early-stage breast cancer.

Authors:  Jessica A Miller; Julie E Lang; Michele Ley; Ray Nagle; Chiu-Hsieh Hsu; Patricia A Thompson; Catherine Cordova; Amy Waer; H-H Sherry Chow
Journal:  Cancer Prev Res (Phila)       Date:  2013-04-03

Review 4.  Odorant Metabolism in Humans.

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Journal:  Angew Chem Int Ed Engl       Date:  2022-07-28       Impact factor: 16.823
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