Genotype-adjusted familial correlation analysis using three generalized estimating equations.

We analyze familial correlation of a memory score from Caribbean Hispanic families that have multiple family members affected with Alzheimer's disease, adjusting for having at least one APOE-epsilon4 allele, as well as other confounders. To enhance the efficiency of correlation model, this paper proposes an alternative approach for three generalized estimating equations proposed by Yan and Fine (Statist. Med. 2004; 23:859-874). The efficiency of correlation model is evaluated through the asymptotic relative efficiency computation and simulations.