Literature DB >> 18569346

alpha-Chymotrypsin inhibition studies on the lignans from Vitex negundo Linn.

Muhammad Arif Lodhi1, M Iqbal Choudhary, Abdul Malik, Saeed Ahmad.   

Abstract

The lignans (1-8) isolated from the roots of Vitex negundo Linn. were screened against the serine proteases alpha-chymotrypsin, thrombin and prolyl endopeptidase. Compounds 3 and 4 were found to be active only against alpha-chymotrypsin and were noncompetitive and competitive inhibitors of the enzyme, respectively. Ki values were found to be in the range 31.75-47.11 microM.

Entities:  

Mesh：

Substances：

Year:  2008        PMID： 18569346     DOI： 10.1080/14756360701584653

Source DB:  PubMed          Journal:  J Enzyme Inhib Med Chem        ISSN： 1475-6366            Impact factor:   5.051


  4 in total

1.  Chemical Constituents from the Aerial Parts of Cyrtopodium paniculatum.

Authors:  Florence Auberon; Opeyemi Joshua Olatunji; Gaëtan Herbette; Diamondra Raminoson; Cyril Antheaume; Beatriz Soengas; Frédéric Bonté; Annelise Lobstein
Journal:  Molecules       Date:  2016-10-24       Impact factor: 4.411

2.  Vitex negundo inhibits cyclooxygenase-2 inflammatory cytokine-mediated inflammation on carrageenan-induced rat hind paw edema.

Authors:  Pronobesh Chattopadhyay; Soilyadhar Hazarika; Sunil Dhiman; Aadesh Upadhyay; Anurag Pandey; Sanjeev Karmakar; Lokendra Singh
Journal:  Pharmacognosy Res       Date:  2012-07

Review 3.  The genus Vitex: A review.

Authors:  Anita Rani; Anupam Sharma
Journal:  Pharmacogn Rev       Date:  2013-07

Review 4.  Nor-Lignans: Occurrence in Plants and Biological Activities-A Review.

Authors:  Claudio Frezza; Alessandro Venditti; Chiara Toniolo; Daniela De Vita; Marco Franceschin; Antonio Ventrone; Lamberto Tomassini; Sebastiano Foddai; Marcella Guiso; Marcello Nicoletti; Mauro Serafini; Armandodoriano Bianco
Journal:  Molecules       Date:  2020-01-03       Impact factor: 4.411
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.