PRIMARY OBJECTIVE: There has been increasing interest in the role of cholinomimetic agents in the long-term management of cognitive impairment following traumatic brain injury. This paper aims to assess the evidence accumulated thus far. METHODS: Studies are identified by searching MEDLINE, EMBASE and PsychINFO, contacting experts and pharmaceutical companies and hand searching bibliographies. All study designs are included. MAIN OUTCOME AND RESULTS: This study identified 25 papers that studied cholinesterase inhibitors, physostigmine and choline in mild-to-severe traumatic brain injury. The outcome with cholinesterase inhibitors and choline is suggestive but not conclusive while physostigmine appears of little benefit. A lack of rigorous studies and a plethora of outcome measures preclude drawing definitive conclusions. Further randomized controlled trials are urgently required.
PRIMARY OBJECTIVE: There has been increasing interest in the role of cholinomimetic agents in the long-term management of cognitive impairment following traumatic brain injury. This paper aims to assess the evidence accumulated thus far. METHODS: Studies are identified by searching MEDLINE, EMBASE and PsychINFO, contacting experts and pharmaceutical companies and hand searching bibliographies. All study designs are included. MAIN OUTCOME AND RESULTS: This study identified 25 papers that studied cholinesterase inhibitors, physostigmine and choline in mild-to-severe traumatic brain injury. The outcome with cholinesterase inhibitors and choline is suggestive but not conclusive while physostigmine appears of little benefit. A lack of rigorous studies and a plethora of outcome measures preclude drawing definitive conclusions. Further randomized controlled trials are urgently required.
Authors: Walter M High; Maria Briones-Galang; Jessica A Clark; Charles Gilkison; Kurt A Mossberg; Dennis J Zgaljardic; Brent E Masel; Randall J Urban Journal: J Neurotrauma Date: 2010-09 Impact factor: 5.269
Authors: David Tweedie; Koji Fukui; Yazhou Li; Qian-Sheng Yu; Shani Barak; Ian A Tamargo; Vardit Rubovitch; Harold W Holloway; Elin Lehrmann; William H Wood; Yongqing Zhang; Kevin G Becker; Evelyn Perez; Henriette Van Praag; Yu Luo; Barry J Hoffer; Robert E Becker; Chaim G Pick; Nigel H Greig Journal: PLoS One Date: 2016-06-02 Impact factor: 3.240
Authors: Barry J Hoffer; Chaim G Pick; Michael E Hoffer; Robert E Becker; Yung-Hsiao Chiang; Nigel H Greig Journal: J Biomed Sci Date: 2017-09-09 Impact factor: 8.410