Literature DB >> 18566902

Effect of Benzene on liver functions in rats (Rattus norvegicus).

Egemen Dere1, Ferda Ari.   

Abstract

Rats (Rattus norvegicus) were intraperitoneally injected with a 100 mg kg(-1) dosage of benzene, a toxic and carcinogenic agent widely used for industrial purposes. Changes in lactate dehydrogenase (LDH), alkaline phosphatase (ALP), alanine amino transferase (ALT), aspartate amino transferase (AST) activities in serum of rats were investigated at 2, 4, 8, 16, 32, and 64 h following injection. Serum physiological was administered to control group. Activities were measured using autoanalyzer. Benzene caused significant activations in LDH, ALP, and AST activities in the serum at some test hours (p < 0.05). When compared with the control groups, although an increase occurred in ALT activity, it was seem that this increase wasn't significant (p > 0.05).

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Year:  2008        PMID： 18566902     DOI： 10.1007/s10661-008-0374-7

Source DB:  PubMed          Journal:  Environ Monit Assess        ISSN： 0167-6369            Impact factor:   2.513


  24 in total

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