Literature DB >> 18566739

Variation of the oxytocin/neurophysin I (OXT) gene in four human populations.

Yang Xu1,2, Yali Xue1, Allan Daly1, Lijie Wu3, Chris Tyler-Smith4.   

Abstract

Oxytocin is a short peptide with multiple functions in human biology and has been implicated in autism. We aimed to determine the normal pattern of variation around the oxytocin gene and resequenced it and its flanking regions in 91 individuals from four HapMap populations and one chimpanzee. We identified 14 single nucleotide polymorphisms (SNPs), all noncoding, including eight that were novel. Population genetic analyses were largely consistent with a neutral evolutionary history, but an Hudson-Kreitman-Aguadé (HKA) test revealed more variation within the human population than expected from the level of chimpanzee-human divergence.

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Year:  2008        PMID： 18566739      PMCID： PMC2680061          DOI： 10.1007/s10038-008-0292-0

Source DB:  PubMed          Journal:  J Hum Genet        ISSN： 1434-5161            Impact factor:   3.172


  19 in total

1.  A new statistical method for haplotype reconstruction from population data.

Authors:  M Stephens; N J Smith; P Donnelly
Journal:  Am J Hum Genet       Date:  2001-03-09       Impact factor: 11.025

2.  Median-joining networks for inferring intraspecific phylogenies.

Authors:  H J Bandelt; P Forster; A Röhl
Journal:  Mol Biol Evol       Date:  1999-01       Impact factor: 16.240

3.  DnaSP, DNA polymorphism analyses by the coalescent and other methods.

Authors:  Julio Rozas; Juan C Sánchez-DelBarrio; Xavier Messeguer; Ricardo Rozas
Journal:  Bioinformatics       Date:  2003-12-12       Impact factor: 6.937

4.  Haploview: analysis and visualization of LD and haplotype maps.

Authors:  J C Barrett; B Fry; J Maller; M J Daly
Journal:  Bioinformatics       Date:  2004-08-05       Impact factor: 6.937

5.  A test of neutral molecular evolution based on nucleotide data.

Authors:  R R Hudson; M Kreitman; M Aguadé
Journal:  Genetics       Date:  1987-05       Impact factor: 4.562

6.  Statistical tests of neutrality of mutations.

Authors:  Y X Fu; W H Li
Journal:  Genetics       Date:  1993-03       Impact factor: 4.562

7.  Plasma oxytocin levels in autistic children.

Authors:  C Modahl; L Green; D Fein; M Morris; L Waterhouse; C Feinstein; H Levin
Journal:  Biol Psychiatry       Date:  1998-02-15       Impact factor: 13.382

8.  Evolutionary and biomedical insights from the rhesus macaque genome.

Authors:  Richard A Gibbs; Jeffrey Rogers; Michael G Katze; Roger Bumgarner; George M Weinstock; Elaine R Mardis; Karin A Remington; Robert L Strausberg; J Craig Venter; Richard K Wilson; Mark A Batzer; Carlos D Bustamante; Evan E Eichler; Matthew W Hahn; Ross C Hardison; Kateryna D Makova; Webb Miller; Aleksandar Milosavljevic; Robert E Palermo; Adam Siepel; James M Sikela; Tony Attaway; Stephanie Bell; Kelly E Bernard; Christian J Buhay; Mimi N Chandrabose; Marvin Dao; Clay Davis; Kimberly D Delehaunty; Yan Ding; Huyen H Dinh; Shannon Dugan-Rocha; Lucinda A Fulton; Ramatu Ayiesha Gabisi; Toni T Garner; Jennifer Godfrey; Alicia C Hawes; Judith Hernandez; Sandra Hines; Michael Holder; Jennifer Hume; Shalini N Jhangiani; Vandita Joshi; Ziad Mohid Khan; Ewen F Kirkness; Andrew Cree; R Gerald Fowler; Sandra Lee; Lora R Lewis; Zhangwan Li; Yih-Shin Liu; Stephanie M Moore; Donna Muzny; Lynne V Nazareth; Dinh Ngoc Ngo; Geoffrey O Okwuonu; Grace Pai; David Parker; Heidie A Paul; Cynthia Pfannkoch; Craig S Pohl; Yu-Hui Rogers; San Juana Ruiz; Aniko Sabo; Jireh Santibanez; Brian W Schneider; Scott M Smith; Erica Sodergren; Amanda F Svatek; Teresa R Utterback; Selina Vattathil; Wesley Warren; Courtney Sherell White; Asif T Chinwalla; Yucheng Feng; Aaron L Halpern; Ladeana W Hillier; Xiaoqiu Huang; Pat Minx; Joanne O Nelson; Kymberlie H Pepin; Xiang Qin; Granger G Sutton; Eli Venter; Brian P Walenz; John W Wallis; Kim C Worley; Shiaw-Pyng Yang; Steven M Jones; Marco A Marra; Mariano Rocchi; Jacqueline E Schein; Robert Baertsch; Laura Clarke; Miklós Csürös; Jarret Glasscock; R Alan Harris; Paul Havlak; Andrew R Jackson; Huaiyang Jiang; Yue Liu; David N Messina; Yufeng Shen; Henry Xing-Zhi Song; Todd Wylie; Lan Zhang; Ewan Birney; Kyudong Han; Miriam K Konkel; Jungnam Lee; Arian F A Smit; Brygg Ullmer; Hui Wang; Jinchuan Xing; Richard Burhans; Ze Cheng; John E Karro; Jian Ma; Brian Raney; Xinwei She; Michael J Cox; Jeffery P Demuth; Laura J Dumas; Sang-Gook Han; Janet Hopkins; Anis Karimpour-Fard; Young H Kim; Jonathan R Pollack; Tomas Vinar; Charles Addo-Quaye; Jeremiah Degenhardt; Alexandra Denby; Melissa J Hubisz; Amit Indap; Carolin Kosiol; Bruce T Lahn; Heather A Lawson; Alison Marklein; Rasmus Nielsen; Eric J Vallender; Andrew G Clark; Betsy Ferguson; Ryan D Hernandez; Kashif Hirani; Hildegard Kehrer-Sawatzki; Jessica Kolb; Shobha Patil; Ling-Ling Pu; Yanru Ren; David Glenn Smith; David A Wheeler; Ian Schenck; Edward V Ball; Rui Chen; David N Cooper; Belinda Giardine; Fan Hsu; W James Kent; Arthur Lesk; David L Nelson; William E O'brien; Kay Prüfer; Peter D Stenson; James C Wallace; Hui Ke; Xiao-Ming Liu; Peng Wang; Andy Peng Xiang; Fan Yang; Galt P Barber; David Haussler; Donna Karolchik; Andy D Kern; Robert M Kuhn; Kayla E Smith; Ann S Zwieg
Journal:  Science       Date:  2007-04-13       Impact factor: 47.728

Review 9.  Sex differences in oxytocin and vasopressin: implications for autism spectrum disorders?

Authors:  C Sue Carter
Journal:  Behav Brain Res       Date:  2006-09-25       Impact factor: 3.332

10.  Strong association of de novo copy number mutations with autism.

Authors:  Jonathan Sebat; B Lakshmi; Dheeraj Malhotra; Jennifer Troge; Christa Lese-Martin; Tom Walsh; Boris Yamrom; Seungtai Yoon; Alex Krasnitz; Jude Kendall; Anthony Leotta; Deepa Pai; Ray Zhang; Yoon-Ha Lee; James Hicks; Sarah J Spence; Annette T Lee; Kaija Puura; Terho Lehtimäki; David Ledbetter; Peter K Gregersen; Joel Bregman; James S Sutcliffe; Vaidehi Jobanputra; Wendy Chung; Dorothy Warburton; Mary-Claire King; David Skuse; Daniel H Geschwind; T Conrad Gilliam; Kenny Ye; Michael Wigler
Journal:  Science       Date:  2007-03-15       Impact factor: 47.728
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  2 in total

Review 1.  The challenge of translation in social neuroscience: a review of oxytocin, vasopressin, and affiliative behavior.

Authors:  Thomas R Insel
Journal:  Neuron       Date:  2010-03-25       Impact factor: 17.173

2.  Epigenetic modification of OXT and human sociability.

Authors:  Brian W Haas; Megan M Filkowski; R Nick Cochran; Lydia Denison; Alexandra Ishak; Shota Nishitani; Alicia K Smith
Journal:  Proc Natl Acad Sci U S A       Date:  2016-06-20       Impact factor: 11.205
  2 in total

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