Literature DB >> 18566569

Genes controlling spread of breast cancer to lung "gang of 4".

S A Eltarhouny1, W H Elsawy, R Radpour, S Hahn, W Holzgreve, X Y Zhong.   

Abstract

Cancer-related mortality is caused in a large part by the metastasis of primary tumor. Each cancer has a particular way of spreading cancerous cells. Recently, genetic and pharmacological analysis identified the set of genes, such as epidermal growth factor receptor ligand epiregulin (EREG), cyclooxygenase-2 (COX2) and matrix metalloproteinases 1 and 2 (MMP-1 and MMP-2) that have been found to be associated with metastasis of breast cancer to lung. Inhibition of EGFR and COX2 could minimize lung metastasis of breast cancer in a clinical setting. In this review, we summarized the current knowledge on EREG, COX2, MMP-1 and MMP-2 in tumor development and metastasis.

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Year:  2008        PMID： 18566569

Source DB:  PubMed          Journal:  Exp Oncol        ISSN： 1812-9269


  13 in total

1.  What does matrix metalloproteinase-1 expression in patients with breast cancer really tell us?

Authors:  Ferdinando Mannello
Journal:  BMC Med       Date:  2011-08-11       Impact factor: 8.775

2.  Mammary tumorigenesis induced by fibroblast growth factor receptor 1 requires activation of the epidermal growth factor receptor.

Authors:  Lindsey K Bade; Jodi E Goldberg; Hazel A Dehut; Majken K Hall; Kathryn L Schwertfeger
Journal:  J Cell Sci       Date:  2011-08-24       Impact factor: 5.285

3.  Age-dependent loss of MMP-3 in Hutchinson-Gilford progeria syndrome.

Authors:  Ingrid A Harten; Rima S Zahr; Joan M Lemire; Jason T Machan; Marsha A Moses; Robert J Doiron; Adam S Curatolo; Frank G Rothman; Thomas N Wight; Bryan P Toole; Leslie B Gordon
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2011-08-17       Impact factor: 6.053

4.  Tumor-stromal interactions of the bone microenvironment: in vitro findings and potential in vivo relevance in metastatic lung cancer models.

Authors:  Diego Luis-Ravelo; Iker Antón; Silvestre Vicent; Igor Hernández; Karmele Valencia; Carolina Zandueta; Susana Martínez-Canarias; Alfonso Gúrpide; Fernando Lecanda
Journal:  Clin Exp Metastasis       Date:  2011-07-28       Impact factor: 5.150

5.  Demonstration of anti-tumor activity of oncolytic measles virus strains in a malignant pleural effusion breast cancer model.

Authors:  Ianko D Iankov; Pavlos Msaouel; Cory Allen; Mark J Federspiel; Peggy A Bulur; Allan B Dietz; Dennis Gastineau; Yasuhiro Ikeda; James N Ingle; Stephen J Russell; Evanthia Galanis
Journal:  Breast Cancer Res Treat       Date:  2009-11-06       Impact factor: 4.872

6.  Epiregulin enhances tumorigenicity by activating the ERK/MAPK pathway in glioblastoma.

Authors:  Shinji Kohsaka; Kunihiko Hinohara; Lei Wang; Tatsunori Nishimura; Masana Urushido; Kazuhiro Yachi; Masumi Tsuda; Mishie Tanino; Taichi Kimura; Hiroshi Nishihara; Noriko Gotoh; Shinya Tanaka
Journal:  Neuro Oncol       Date:  2014-07       Impact factor: 12.300

7.  CXCR4 and matrix metalloproteinase-1 are elevated in breast carcinoma-associated fibroblasts and in normal mammary fibroblasts exposed to factors secreted by breast cancer cells.

Authors:  Sarah M Eck; Anik L Côté; William D Winkelman; Constance E Brinckerhoff
Journal:  Mol Cancer Res       Date:  2009-07-07       Impact factor: 5.852

8.  Epiregulin contributes to breast tumorigenesis through regulating matrix metalloproteinase 1 and promoting cell survival.

Authors:  Mariya Farooqui; Laura R Bohrer; Nicholas J Brady; Pavlina Chuntova; Sarah E Kemp; C Taylor Wardwell; Andrew C Nelson; Kathryn L Schwertfeger
Journal:  Mol Cancer       Date:  2015-07-29       Impact factor: 27.401

9.  p130Cas/Cyclooxygenase-2 axis in the control of mesenchymal plasticity of breast cancer cells.

Authors:  Brigitte Bisaro; Maura Montani; Georgia Konstantinidou; Cristina Marchini; Lucia Pietrella; Manuela Iezzi; Mirco Galiè; Francesca Orso; Annalisa Camporeale; Shana M Colombo; Paola Di Stefano; Giusy Tornillo; Maria P Camacho-Leal; Emilia Turco; Daniela Taverna; Sara Cabodi; Augusto Amici; Paola Defilippi
Journal:  Breast Cancer Res       Date:  2012-10-26       Impact factor: 6.466

10.  Autocrine epiregulin activates EGFR pathway for lung metastasis via EMT in salivary adenoid cystic carcinoma.

Authors:  Shuli Liu; Dongxia Ye; Dongliang Xu; Yueling Liao; Ling Zhang; Liu Liu; Wenwen Yu; Yanan Wang; Yue He; Jingzhou Hu; Wenzheng Guo; Tong Wang; Beibei Sun; Hongyong Song; Huijing Yin; Jingyi Liu; Yadi Wu; Hanguang Zhu; Binhua P Zhou; Jiong Deng; Zhiyuan Zhang
Journal:  Oncotarget       Date:  2016-05-03
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