Literature DB >> 18565754

Synthesis and biological activity of some new flavonyl-2,4-thiazolidinediones.

Oya Bozdağ-Dündar1, Eugen J Verspohl, Net Daş-Evcimen, Rebecca M Kaup, Katrin Bauer, Mutlu Sarikaya, Begüm Evranos, Rahmiye Ertan.   

Abstract

A new series of flavonyl-2,4-thiazolidinediones (Va-c, VIa-c) was prepared by Knoevenagel reaction. The synthesized compounds were tested for their ability to inhibit rat kidney aldose reductase (AR) and for their insulinotropic activities in INS-1 cells. Compound Vb was able to increase insulin release in the presence of 5.6mmol/l glucose. Compounds VIa-c displayed moderate to high AR inhibitory activity levels. Particularly, compound VIa showed the highest AR inhibitory activity (86.57%).

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Year:  2008        PMID： 18565754     DOI： 10.1016/j.bmc.2008.05.059

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  6 in total

1.  Synthesis and Aldose Reductase Inhibitory Effect of Some New Hydrazinecarbothioamides and 4-Thiazolidinones Bearing an Imidazo[2,1-b]Thiazole Moiety.

Authors:  Nuray Ulusoy Güzeldemirci; Selin Cimok; Net Daş-Evcimen; Mutlu Sarikaya
Journal:  Turk J Pharm Sci       Date:  2018-12-31

2.  Synthesis of new pyrazolyl-2, 4-thiazolidinediones as antibacterial and antifungal agents.

Authors:  Deepak K Aneja; Poonam Lohan; Sanjiv Arora; Chetan Sharma; Kamal R Aneja; Om Prakash
Journal:  Org Med Chem Lett       Date:  2011-11-08

Review 3.  5-Ene-4-thiazolidinones - An efficient tool in medicinal chemistry.

Authors:  Danylo Kaminskyy; Anna Kryshchyshyn; Roman Lesyk
Journal:  Eur J Med Chem       Date:  2017-09-20       Impact factor: 6.514

Review 4.  An overview on medicinal perspective of thiazolidine-2,4-dione: A remarkable scaffold in the treatment of type 2 diabetes.

Authors:  Garima Bansal; Punniyakoti Veeraveedu Thanikachalam; Rahul K Maurya; Pooja Chawla; Srinivasan Ramamurthy
Journal:  J Adv Res       Date:  2020-01-22       Impact factor: 10.479

Review 5.  Thiazolidinediones: An In-Depth Study of Their Synthesis and Application to Medicinal Chemistry in the Treatment of Diabetes Mellitus.

Authors:  Nathan Long; Adam Le Gresley; Stephen P Wren
Journal:  ChemMedChem       Date:  2021-05-04       Impact factor: 3.466

6.  Development of new 5-(chromene-3-yl)methylene-2,4-thiazolidinediones as antimicrobial agents.

Authors:  Cristina Mariana Nastasă; Mihaela Duma; Adrian Pîrnău; Laurian Vlase; Brînduşa Tiperciuc; Ovidiu Oniga
Journal:  Clujul Med       Date:  2016-01-15
  6 in total

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