| Literature DB >> 18565646 |
Yunxia Feng1, Jianzhong Zhang, Liping Dai, Jianying Zhang, Peng Wang, Jing Zang, Yuchun Li, Kaijuan Wang.
Abstract
The purpose of this study was to test the associations about Helicobacter pylori infection and polymorphisms of IL-1B-31/-511 and IL-1RN VNTR polymorphism with gastric cancer in cases' and controls' family members from the areas of high cancer prevalence in China. IL-1B-511T and IL-1RN *2 were associated with risks of gastric cancer. The association strength reduced with the relative degree decreasing. Such association was not found in the polymorphisms of IL-1B-31. But the haplotype analysis of IL-1B-511 and IL-1B-31 genotype could enhance the risks of gastric cancer. The positive H. pylori status could increase the risks of IL-1B to gastric cancer.Entities:
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Year: 2008 PMID: 18565646 DOI: 10.1016/j.canlet.2008.05.013
Source DB: PubMed Journal: Cancer Lett ISSN: 0304-3835 Impact factor: 8.679