Literature DB >> 18565645

Synthetic chenodeoxycholic acid derivative, HS-1200, induces apoptosis of human hepatoma cells via a mitochondrial pathway.

Hui Liu1, Cheng-Kun Qin, Guo-Qing Han, Hong-Wei Xu, Wan-Hua Ren, Cheng-Yong Qin.   

Abstract

We investigated whether HS-1200 has anti-proliferation effects on human hepatoma cells in vitro. Here, chromatin condensation, DNA ladder formation and proteolytic cleavage of poly (ADP-ribose) polymerase (PARP) were observed after treatment of HS-1200, indicating the occurrence of apoptotic cell death, which was associated with up-regulation of Bax, cleaved-caspase-3 and cleaved-caspase-9. Inhibition of caspase-9 rescued HS-1200-induced apoptosis. Furthermore, cells treated with HS-1200 showed a reduction in mitochondrial membrane potential (Deltapsi(m)) and caused cytochrome c release into the cytosol. The results indicated that synthetic chenodeoxycholic acid HS-1200 could induce cell apoptosis in BEL7402 human hepatoma cell line, via a Bax/cytochrome c/caspase-9 independent pathway. This study suggested that HS-1200 is potentially useful as an apoptosis inducer for the treatment of hepatocellular carcinoma.

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Year:  2008        PMID: 18565645     DOI: 10.1016/j.canlet.2008.05.014

Source DB:  PubMed          Journal:  Cancer Lett        ISSN: 0304-3835            Impact factor:   8.679


  9 in total

1.  Ursodeoxycholic acid induces apoptosis in hepatocellular carcinoma xenografts in mice.

Authors:  Hui Liu; Hong-Wei Xu; Yu-Zhen Zhang; Ya Huang; Guo-Qing Han; Tie-Jun Liang; Li-Li Wei; Cheng-Yong Qin; Cheng-Kun Qin
Journal:  World J Gastroenterol       Date:  2015-09-28       Impact factor: 5.742

2.  Chenodeoxycholic Acid Derivative HS-1200 Inhibits Hepatocarcinogenesis and Improves Liver Function in Diethylnitrosamine-Exposed Rats by Downregulating MTH1.

Authors:  Miao Xu; Qi Zhao; Donghui Shao; Hui Liu; Jianni Qi; Chengyong Qin
Journal:  Biomed Res Int       Date:  2017-02-05       Impact factor: 3.411

3.  MicroRNA‑124 improves functional recovery and suppresses Bax‑dependent apoptosis in rats following spinal cord injury.

Authors:  Zhongyang Xu; Kefeng Zhang; Qian Wang; Yanping Zheng
Journal:  Mol Med Rep       Date:  2019-01-28       Impact factor: 2.952

4.  miR-142-3p suppresses apoptosis in spinal cord-injured rats.

Authors:  Jun Zheng; Jing Kuang; Xianyu Zhang; Daya Luo; Weijing Liao
Journal:  Transl Neurosci       Date:  2020-05-18       Impact factor: 1.757

Review 5.  Physiology and Physical Chemistry of Bile Acids.

Authors:  Maria Chiara di Gregorio; Jacopo Cautela; Luciano Galantini
Journal:  Int J Mol Sci       Date:  2021-02-10       Impact factor: 5.923

6.  Chenodeoxycholic Acid Enhances the Effect of Sorafenib in Inhibiting HepG2 Cell Growth Through EGFR/Stat3 Pathway.

Authors:  Yang Zhang; Yan Zhang; Xiao-Jun Shi; Jun-Xiang Li; Lin-Heng Wang; Chun-E Xie; Yun-Liang Wang
Journal:  Front Oncol       Date:  2022-02-17       Impact factor: 6.244

Review 7.  Mechanism of Bile Acid-Induced Programmed Cell Death and Drug Discovery against Cancer: A Review.

Authors:  Jung Yoon Jang; Eunok Im; Yung Hyun Choi; Nam Deuk Kim
Journal:  Int J Mol Sci       Date:  2022-06-28       Impact factor: 6.208

8.  Suppression of cholangiocarcinoma cell growth by human umbilical cord mesenchymal stem cells: a possible role of Wnt and Akt signaling.

Authors:  Juan Liu; Guoqing Han; Hui Liu; Chengyong Qin
Journal:  PLoS One       Date:  2013-04-30       Impact factor: 3.240

9.  MicroRNA-466c-3p exerts protective effect on neuronal apoptosis and improves functional recovery post spinal cord injury via mitochondrial apoptotic pathway.

Authors:  Yan An; Jianing Li; Qiang Yuan; Mingxing Fan
Journal:  AMB Express       Date:  2020-06-15       Impact factor: 3.298

  9 in total

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