Literature DB >> 18565496

Increased electrical and metabolic activity in the dorsal raphe nucleus of Parkinsonian rats.

Ahmet H Kaya1, Rinske Vlamings, Sonny Tan, Lee Wei Lim, Peter J Magill, Harry W M Steinbusch, Veerle Visser-Vandewalle, Trevor Sharp, Yasin Temel.   

Abstract

Serotonin (5-HT) containing neurons in the dorsal raphe nucleus (DRN) may play important roles in Parkinson's disease (PD). This study investigated neural and metabolic activity of the DRN in animal PD models based on dopamine depletion. The data show both increased firing rate of DRN 5-HT neurons and increased cytochrome oxidase activity in dopamine-depleted rats, as compared to controls. These data support the hypothesis that the DRN 5-HT system is hyperactive in the dopamine-depleted brain.

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Year:  2008        PMID： 18565496     DOI： 10.1016/j.brainres.2008.05.019

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  7 in total

1.  Behavioral and neurochemical effects of chronic L-DOPA treatment on nonmotor sequelae in the hemiparkinsonian rat.

Authors:  Karen L Eskow Jaunarajs; Kristin B Dupre; Corinne Y Ostock; Thomas Button; Terrence Deak; Christopher Bishop
Journal:  Behav Pharmacol       Date:  2010-10       Impact factor: 2.293

Review 2.  Contribution of serotonergic transmission to the motor and cognitive effects of high-frequency stimulation of the subthalamic nucleus or levodopa in Parkinson's disease.

Authors:  Sylvia Navailles; Philippe De Deurwaerdère
Journal:  Mol Neurobiol       Date:  2012-01-06       Impact factor: 5.590

3.  Computational studies of the role of serotonin in the basal ganglia.

Authors:  Michael C Reed; H Frederik Nijhout; Janet Best
Journal:  Front Integr Neurosci       Date:  2013-05-24

Review 4.  Interaction between the 5-HT system and the basal ganglia: functional implication and therapeutic perspective in Parkinson's disease.

Authors:  Cristina Miguelez; Teresa Morera-Herreras; Maria Torrecilla; Jose A Ruiz-Ortega; Luisa Ugedo
Journal:  Front Neural Circuits       Date:  2014-03-17       Impact factor: 3.492

Review 5.  Impairment of Serotonergic Transmission by the Antiparkinsonian Drug L-DOPA: Mechanisms and Clinical Implications.

Authors:  Cristina Miguelez; Abdelhamid Benazzouz; Luisa Ugedo; Philippe De Deurwaerdère
Journal:  Front Cell Neurosci       Date:  2017-09-12       Impact factor: 5.505

6.  Motor cortico-nigral and cortico-entopeduncular information transmission and its modulation by buspirone in control and after dopaminergic denervation.

Authors:  Sergio Vegas-Suárez; Teresa Morera-Herreras; Catalina Requejo; José Vicente Lafuente; Rosario Moratalla; Cristina Miguélez; Luisa Ugedo
Journal:  Front Pharmacol       Date:  2022-08-30       Impact factor: 5.988

7.  The acute and long-term L-DOPA effects are independent from changes in the activity of dorsal raphe serotonergic neurons in 6-OHDA lesioned rats.

Authors:  C Miguelez; S Navailles; P De Deurwaerdère; L Ugedo
Journal:  Br J Pharmacol       Date:  2016-03-08       Impact factor: 8.739
  7 in total

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