Literature DB >> 18565482

Bone morphogenetic protein 7 (BMP7): a critical role in kidney development and a putative modulator of kidney injury.

Patrick Archdeacon1, Randal K Detwiler.   

Abstract

Bone morphogenetic protein 7 (BMP7), a member of the tumor growth factor beta superfamily, appears to have a role in both kidney development and response to kidney injury. Signals through its pathways permit both epithelial differentiation during embryogenesis and preservation of normal kidney architecture after stress, leading to the hypothesis that BMP7 may exert its kidney-protective effects in adult animals by preventing or reversing epithelial-to-mesenchymal transformation. This review attempts to synthesize the data supporting those conclusions and suggest some future areas of research.

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Year:  2008        PMID： 18565482     DOI： 10.1053/j.ackd.2008.04.011

Source DB:  PubMed          Journal:  Adv Chronic Kidney Dis        ISSN： 1548-5595            Impact factor:   3.620


  6 in total

1.  Matrilysin (MMP-7) inhibition of BMP-7 induced renal tubular branching morphogenesis suggests a role in the pathogenesis of human renal dysplasia.

Authors:  John K McGuire; Susanna Harju-Baker; Cliff Rims; Joong-Hyuk Sheen; Helen Liapis
Journal:  J Histochem Cytochem       Date:  2012-01-03       Impact factor: 2.479

2.  Activin-like kinase 3 is important for kidney regeneration and reversal of fibrosis.

Authors:  Hikaru Sugimoto; Valerie S LeBleu; Dattatreyamurty Bosukonda; Peter Keck; Gangadhar Taduri; Wibke Bechtel; Hirokazu Okada; William Carlson; Philippe Bey; Mary Rusckowski; Björn Tampe; Desiree Tampe; Keizo Kanasaki; Michael Zeisberg; Raghu Kalluri
Journal:  Nat Med       Date:  2012-02-05       Impact factor: 53.440

3.  Salvianolic acid A alleviates the renal damage in rats with chronic renal failure1.

Authors:  Guangming Zhang; Guanghua Cui; Shuangxi Tong; Qingxian Cao
Journal:  Acta Cir Bras       Date:  2019-02-28       Impact factor: 1.388

4.  Class IIa histone deacetylase inhibition ameliorates acute kidney injury by suppressing renal tubular cell apoptosis and enhancing autophagy and proliferation.

Authors:  Jialu Li; Chao Yu; Fengchen Shen; Binbin Cui; Na Liu; Shougang Zhuang
Journal:  Front Pharmacol       Date:  2022-07-22       Impact factor: 5.988

5.  A potential adjuvant chemotherapeutics, 18β-glycyrrhetinic acid, inhibits renal tubular epithelial cells apoptosis via enhancing BMP-7 epigenetically through targeting HDAC2.

Authors:  Taotao Ma; Cheng Huang; Xiaoming Meng; Xiaofeng Li; Yilong Zhang; Shuai Ji; Jun Li; Min Ye; Hong Liang
Journal:  Sci Rep       Date:  2016-05-05       Impact factor: 4.379

Review 6.  Roles and regulation of bone morphogenetic protein-7 in kidney development and diseases.

Authors:  Taro Tsujimura; Mana Idei; Masahiro Yoshikawa; Osamu Takase; Keiichi Hishikawa
Journal:  World J Stem Cells       Date:  2016-09-26       Impact factor: 5.326
  6 in total

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