M Palta1, M Sadek-Badawi, D P Carlton. 1. Department of Population Health Sciences, University of Wisconsin-Madison, Madison, WI 53726, USA. mpalta@wisc.edu
Abstract
OBJECTIVE: To investigate associations between early low neutrophil count from routine blood samples, white blood count (WBC), pregnancy complications and neonatal outcomes for very low birth weight infants (VLBW <or=1500 g) with gestational age <32 weeks. STUDY DESIGN: Information was abstracted on all infants admitted to level III neonatal intensive care units in Wisconsin 2003 to 2004. A total of 1002 VLBW neonates (78%) had differential and corrected total white counts within 2 (1/2) h of birth. Data analyses included frequency tables, binary logistic, ordinal logistic and ordinary regression. RESULT: Low neutrophil count (<1000 per microl) was strongly associated with low WBC, pregnancy complications and antenatal steroids. Low neutrophil count predicted bronchopulmonary dysplasia severity level (odds ratio, OR: 1.7, 95% confidence interval, CI: 1.1 to 2.7) and intraventricular hemorrhage grade (OR: 2.2, 95% CI: 1.3 to 3.8). CONCLUSION: Early neutrophil counts may have multiple causes interfering with their routine use as an inflammatory marker. Nonetheless, low neutrophil count has consistent independent associations with outcomes.
OBJECTIVE: To investigate associations between early low neutrophil count from routine blood samples, white blood count (WBC), pregnancy complications and neonatal outcomes for very low birth weight infants (VLBW <or=1500 g) with gestational age <32 weeks. STUDY DESIGN: Information was abstracted on all infants admitted to level III neonatal intensive care units in Wisconsin 2003 to 2004. A total of 1002 VLBW neonates (78%) had differential and corrected total white counts within 2 (1/2) h of birth. Data analyses included frequency tables, binary logistic, ordinal logistic and ordinary regression. RESULT: Low neutrophil count (<1000 per microl) was strongly associated with low WBC, pregnancy complications and antenatal steroids. Low neutrophil count predicted bronchopulmonary dysplasia severity level (odds ratio, OR: 1.7, 95% confidence interval, CI: 1.1 to 2.7) and intraventricular hemorrhage grade (OR: 2.2, 95% CI: 1.3 to 3.8). CONCLUSION: Early neutrophil counts may have multiple causes interfering with their routine use as an inflammatory marker. Nonetheless, low neutrophil count has consistent independent associations with outcomes.
Authors: Jozef De Dooy; Cecile Colpaert; Annemie Schuerwegh; Chris Bridts; Marc Van Der Planken; Margaretha Ieven; Luc De Clerck; Wim Stevens; Ludo Mahieu Journal: Pediatr Res Date: 2003-04-02 Impact factor: 3.756
Authors: Kristin Haraldsdottir; Andrew M Watson; Kara N Goss; Arij G Beshish; David F Pegelow; Mari Palta; Laura H Tetri; Gregory P Barton; Melissa D Brix; Ryan M Centanni; Marlowe W Eldridge Journal: Physiol Rep Date: 2018-03