BACKGROUND AND OBJECTIVES: It is known that coronary artery calcification (CAC) develops in chronic kidney disease (CKD) before initiation of renal replacement therapy, and factors associated with CKD mineral and bone disorders (CKD-MBDs) are involved. However, little information is available about any association between plasma levels of asymmetric dimethylarginine (ADMA), insulin resistance, and CAC. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: A total of 111 CKD patients (79 men, 32 women; glomerular filtration rate [GFR] median, 33.7 ml/min per 1.73 m(2)), free of cardiovascular disease, were consecutively recruited along with 30 age-matched healthy subjects. Coronary artery calcification scores (CACS) were measured by multidetector-row CT according to Agatston score. RESULTS: In CKD patients, CACS was distributed widely from 0 to 2901, while in age-matched, healthy control subjects (n = 30), CACS showed a range from 0 to 307. GFR had a significant negative correlation with CACS. Plasma ADMA levels were negatively correlated with GFR and positively correlated with CACS. When CACS was divided into quartiles (<50, n = 56; 50 to 300, n = 24; 300 to 600, n = 14; >600, n = 17), the patients with CACS >600 had significantly higher values of HOMA-IR, plasma ADMA levels, and fibrinogen along with serum levels of phosphorus, compared with those in patients having CACS <50. Multivariate regression analysis determined HOMA-IR as an independent contributing factor to CACS. CONCLUSIONS: CAC becomes more prevalent and severe with a decline in GFR, and plasma ADMA levels and insulin resistance, independent of factors associated with CKD-MBD, are correlated with CAC.
BACKGROUND AND OBJECTIVES: It is known that coronary artery calcification (CAC) develops in chronic kidney disease (CKD) before initiation of renal replacement therapy, and factors associated with CKD mineral and bone disorders (CKD-MBDs) are involved. However, little information is available about any association between plasma levels of asymmetric dimethylarginine (ADMA), insulin resistance, and CAC. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: A total of 111 CKDpatients (79 men, 32 women; glomerular filtration rate [GFR] median, 33.7 ml/min per 1.73 m(2)), free of cardiovascular disease, were consecutively recruited along with 30 age-matched healthy subjects. Coronary artery calcification scores (CACS) were measured by multidetector-row CT according to Agatston score. RESULTS: In CKDpatients, CACS was distributed widely from 0 to 2901, while in age-matched, healthy control subjects (n = 30), CACS showed a range from 0 to 307. GFR had a significant negative correlation with CACS. Plasma ADMA levels were negatively correlated with GFR and positively correlated with CACS. When CACS was divided into quartiles (<50, n = 56; 50 to 300, n = 24; 300 to 600, n = 14; >600, n = 17), the patients with CACS >600 had significantly higher values of HOMA-IR, plasma ADMA levels, and fibrinogen along with serum levels of phosphorus, compared with those in patients having CACS <50. Multivariate regression analysis determined HOMA-IR as an independent contributing factor to CACS. CONCLUSIONS: CAC becomes more prevalent and severe with a decline in GFR, and plasma ADMA levels and insulin resistance, independent of factors associated with CKD-MBD, are correlated with CAC.
Authors: K Caglar; M I Yilmaz; A Sonmez; E Cakir; A Kaya; C Acikel; T Eyileten; M Yenicesu; Y Oguz; C Bilgi; C Oktenli; A Vural; C Zoccali Journal: Kidney Int Date: 2006-07-05 Impact factor: 10.612
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Authors: R H Böger; S M Bode-Böger; A Szuba; P S Tsao; J R Chan; O Tangphao; T F Blaschke; J P Cooke Journal: Circulation Date: 1998-11-03 Impact factor: 29.690
Authors: María M Adeva-Andany; Carlos Fernández-Fernández; Lucía Adeva-Contreras; Natalia Carneiro-Freire; Alberto Domínguez-Montero; David Mouriño-Bayolo Journal: Curr Cardiol Rev Date: 2021
Authors: Jiang He; Muredach Reilly; Wei Yang; Jing Chen; Alan S Go; James P Lash; Mahboob Rahman; Chris DeFilippi; Crystal Gadegbeku; Radhika Kanthety; Kaixiang Tao; L Lee Hamm; Akinlolu Ojo; Ray Townsend; Matthew Budoff Journal: Am J Cardiol Date: 2012-09-14 Impact factor: 2.778