Literature DB >> 1856129

The in-vitro activity of drugs against Blastocystis hominis.

L A Dunn1, P F Boreham.   

Abstract

The development of an assay to measure the sensitivity of drugs against Blastocystis hominis using the incorporation of 3H-hypoxanthine is described. The activity of 42 compounds have been measured. Four of the 5-nitroimidazoles tested (satranidazole, S75 0400 A, flunidazole and ronidazole) were found to be more active than metronidazole, the drug commonly used to treat infections caused by B. hominis in humans. Other potentially useful compounds include emetine, furazolidone and quinacrine. Ketoconazole and iodoquinol reported to have therapeutic activity in infections caused by this parasite were found to be significantly less active than metronidazole.

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Year:  1991        PMID： 1856129     DOI： 10.1093/jac/27.4.507

Source DB:  PubMed          Journal:  J Antimicrob Chemother        ISSN： 0305-7453            Impact factor:   5.790


  10 in total

1.  A rapid, high-throughput viability assay for Blastocystis spp. reveals metronidazole resistance and extensive subtype-dependent variations in drug susceptibilities.

Authors:  Haris Mirza; Joshua D W Teo; Jacqui Upcroft; Kevin S W Tan
Journal:  Antimicrob Agents Chemother       Date:  2010-11-22       Impact factor: 5.191

2.  Development of metronidazole-resistant lines of Blastocystis sp.

Authors:  L A Dunn; K S W Tan; P Vanelle; T Juspin; M D Crozet; T Terme; P Upcroft; J A Upcroft
Journal:  Parasitol Res       Date:  2012-02-24       Impact factor: 2.289

Review 3.  Blastocystis hominis revisited.

Authors:  D J Stenzel; P F Boreham
Journal:  Clin Microbiol Rev       Date:  1996-10       Impact factor: 26.132

4.  Axenic culture of Blastocystis hominis in Iscove's modified Dulbecco's medium.

Authors:  L C Ho; M Singh; G Suresh; G C Ng; E H Yap
Journal:  Parasitol Res       Date:  1993       Impact factor: 2.289

5.  In vitro sensitivity of Blastocystis hominis to garlic, ginger, white cumin, and black pepper used in diet.

Authors:  Javed Yakoob; Zaigham Abbas; Muhammad Asim Beg; Shagufta Naz; Safia Awan; Saeed Hamid; Wasim Jafri
Journal:  Parasitol Res       Date:  2011-03-23       Impact factor: 2.289

6.  Blastocystis hominis and the evaluation of efficacy of metronidazole and trimethoprim/sulfamethoxazole.

Authors:  Davood Dorostkar Moghaddam; E Ghadirian; M Azami
Journal:  Parasitol Res       Date:  2005-05-25       Impact factor: 2.289

7.  Pyruvate:ferredoxin oxidoreductase and thioredoxin reductase are involved in 5-nitroimidazole activation while flavin metabolism is linked to 5-nitroimidazole resistance in Giardia lamblia.

Authors:  David Leitsch; Anita G Burgess; Linda A Dunn; Kenia G Krauer; Kevin Tan; Michael Duchêne; Peter Upcroft; Lars Eckmann; Jacqueline A Upcroft
Journal:  J Antimicrob Chemother       Date:  2011-05-22       Impact factor: 5.790

8.  Clinical pilot study: efficacy of triple antibiotic therapy in Blastocystis positive irritable bowel syndrome patients.

Authors:  Robyn Nagel; Helle Bielefeldt-Ohmann; Rebecca Traub
Journal:  Gut Pathog       Date:  2014-08-20       Impact factor: 4.181

9.  Oh my aching gut: irritable bowel syndrome, Blastocystis, and asymptomatic infection.

Authors:  Kenneth F Boorom; Huw Smith; Laila Nimri; Eric Viscogliosi; Gregory Spanakos; Unaiza Parkar; Lan-Hua Li; Xiao-Nong Zhou; Ulgen Z Ok; Saovanee Leelayoova; Morris S Jones
Journal:  Parasit Vectors       Date:  2008-10-21       Impact factor: 3.876

10.  Blastocystis: Consensus of treatment and controversies.

Authors:  Uma Sekar; M Shanthi
Journal:  Trop Parasitol       Date:  2013-01
  10 in total

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