| Literature DB >> 18560976 |
Yoshitaka Uji1, Hiroshi Yamamoto, Tsuyoshi Mori, Hiroya Akabori, Hiroshi Tsuchihashi, Tomoharu Shimizu, Yoshihiro Endo, Tohru Tani.
Abstract
Our aim in this study was to find out whether edaravone (3-methyl-1-phenyl-pyrazolin-5-one, MCI-186), a novel free radical scavenger, improved the survival rate in a rat hemorrhagic shock (HS) model. Fifty male Sprague-Dawley rats were divided randomly into an edaravone group and a saline group. Both groups were subjected to HS by inducing a mean arterial pressure of 30 mmHg for 60 min without resuscitation. The edaravone group was divided into four subgroups based on when edaravone was given: 0, 15, 30, or 60 min after HS. The saline group was given saline immediately after HS. We evaluated the 24-h survival rate in each group. The survival rate of the edaravone subgroup given edaravone immediately after HS was significantly better than that of the saline group. Edaravone improved the survival rate in a rat HS without resuscitation model. Edaravone was most effective when given immediately after HS.Entities:
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Year: 2008 PMID： 18560976 DOI： 10.1007/s00595-007-3666-6
Source DB: PubMed Journal: Surg Today ISSN： 0941-1291 Impact factor: 2.549