BACKGROUND: Although the clinical significance of so-called microbleeds (MBs) in gradient-echo MR images (GRE-MRI) has been extensively researched, the histopathological evaluation is notably insufficient. METHODS: Postmortem GRE-MRI was obtained of water-immersed formalin-fixed tissue blocks from a 97-year-old hypertensive woman with 9 antemortem MBs. Histologic slides were compared with those of MRI. RESULTS: Microscopic examination revealed clusters of hemosiderin-laden macrophages in 8 MBs and arteriolar pseudocalcification in 1 MB in the left pallidum. Hypertensive microangiopathies were found in 5 lesions. The sizes of the lesions with hemosiderin deposits were roughly comparable with the MBs of GRE-MRI. CONCLUSIONS: All of the MBs but for 1 exception were proved to be hemosiderin deposits and frequently associated with hypertensive microangiopathy. (c) 2008 S. Karger AG, Basel.
BACKGROUND: Although the clinical significance of so-called microbleeds (MBs) in gradient-echo MR images (GRE-MRI) has been extensively researched, the histopathological evaluation is notably insufficient. METHODS: Postmortem GRE-MRI was obtained of water-immersed formalin-fixed tissue blocks from a 97-year-old hypertensivewoman with 9 antemortem MBs. Histologic slides were compared with those of MRI. RESULTS: Microscopic examination revealed clusters of hemosiderin-laden macrophages in 8 MBs and arteriolar pseudocalcification in 1 MB in the left pallidum. Hypertensive microangiopathies were found in 5 lesions. The sizes of the lesions with hemosiderin deposits were roughly comparable with the MBs of GRE-MRI. CONCLUSIONS: All of the MBs but for 1 exception were proved to be hemosiderin deposits and frequently associated with hypertensive microangiopathy. (c) 2008 S. Karger AG, Basel.
Authors: Reisa A Sperling; Clifford R Jack; Sandra E Black; Matthew P Frosch; Steven M Greenberg; Bradley T Hyman; Philip Scheltens; Maria C Carrillo; William Thies; Martin M Bednar; Ronald S Black; H Robert Brashear; Michael Grundman; Eric R Siemers; Howard H Feldman; Rachel J Schindler Journal: Alzheimers Dement Date: 2011-07 Impact factor: 21.566
Authors: Muhammad Ayaz; Alexander S Boikov; E Mark Haacke; Daniel K Kido; Wolff M Kirsch Journal: J Magn Reson Imaging Date: 2010-01 Impact factor: 4.813
Authors: Sergi Martinez-Ramirez; Jose-Rafael Romero; Ashkan Shoamanesh; Ann C McKee; Ellis Van Etten; Octavio Pontes-Neto; Eric A Macklin; Alison Ayres; Eitan Auriel; Jayandra J Himali; Alexa S Beiser; Charles DeCarli; Thor D Stein; Victor E Alvarez; Matthew P Frosch; Jonathan Rosand; Steven M Greenberg; M Edip Gurol; Sudha Seshadri; Anand Viswanathan Journal: Alzheimers Dement Date: 2015-06-13 Impact factor: 21.566
Authors: Sven Haller; Max Scheffler; Rares Salomir; François R Herrmann; Gabriel Gold; Marie-Louise Montandon; Enikö Kövari Journal: Neuroradiology Date: 2019-08-08 Impact factor: 2.804
Authors: Andreas Charidimou; Gregoire Boulouis; M Edip Gurol; Cenk Ayata; Brian J Bacskai; Matthew P Frosch; Anand Viswanathan; Steven M Greenberg Journal: Brain Date: 2017-07-01 Impact factor: 13.501
Authors: Allison D Griffin; L Christine Turtzo; Gunjan Y Parikh; Alexander Tolpygo; Zachary Lodato; Anita D Moses; Govind Nair; Daniel P Perl; Nancy A Edwards; Bernard J Dardzinski; Regina C Armstrong; Abhik Ray-Chaudhury; Partha P Mitra; Lawrence L Latour Journal: Brain Date: 2019-11-01 Impact factor: 13.501
Authors: Nicholas M Gregg; Albert E Kim; M Edip Gurol; Oscar L Lopez; Howard J Aizenstein; Julie C Price; Chester A Mathis; Jeffrey A James; Beth E Snitz; Ann D Cohen; M Ilyas Kamboh; Davneet Minhas; Lisa A Weissfeld; Erica L Tamburo; William E Klunk Journal: JAMA Neurol Date: 2015-09 Impact factor: 18.302
Authors: Matthew Schrag; Grant McAuley; Justine Pomakian; Arshad Jiffry; Spencer Tung; Claudius Mueller; Harry V Vinters; E Mark Haacke; Barbara Holshouser; Daniel Kido; Wolff M Kirsch Journal: Acta Neuropathol Date: 2010-03 Impact factor: 17.088
Authors: Steven M Greenberg; Meike W Vernooij; Charlotte Cordonnier; Anand Viswanathan; Rustam Al-Shahi Salman; Steven Warach; Lenore J Launer; Mark A Van Buchem; Monique Mb Breteler Journal: Lancet Neurol Date: 2009-02 Impact factor: 44.182