Literature DB >> 18559281

Transforming growth factor-beta-mediated regulation of BK virus gene expression.

Johanna R Abend1, Michael J Imperiale.   

Abstract

The increasing prevalence of BK virus (BKV)-associated diseases in immunosuppressed patients has prompted an investigation of the immune response to BKV, especially the role of cytokines in regulating viral replication. We examined the effect of TGF-beta, a cytokine that is stimulated by certain immunosuppressive therapies, on BKV gene expression during lytic infection of renal proximal tubule epithelial cells. Viral gene expression, and specifically the activity of the BKV early promoter, is regulated by TGF-beta in a strain-dependent manner. Promoter activity is upregulated in the presence of TGF-beta for the TU strain of BKV, and not for the Dik, Dunlop, or Proto-2 strains. Using site-directed mutagenesis, we have identified a small segment of the TU promoter that is required for stimulation in response to TGF-beta. These results demonstrate that BKV strains can respond differently to cytokine treatment and suggest that TGF-beta may play a role in the reactivation of BKV.

Entities:  

Mesh：

Substances：

Year:  2008        PMID： 18559281      PMCID： PMC2569840          DOI： 10.1016/j.virol.2008.05.009

Source DB:  PubMed          Journal:  Virology        ISSN： 0042-6822            Impact factor:   3.616


  57 in total

Review 1.  Transcriptional control by the TGF-beta/Smad signaling system.

Authors:  J Massagué; D Wotton
Journal:  EMBO J       Date:  2000-04-17       Impact factor: 11.598

Review 2.  TGF-beta in infections and infectious diseases.

Authors:  S G Reed
Journal:  Microbes Infect       Date:  1999-12       Impact factor: 2.700

3.  Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.

Authors:  K J Livak; T D Schmittgen
Journal:  Methods       Date:  2001-12       Impact factor: 3.608

4.  Identification of archetype and rearranged forms of BK virus in leukocytes from healthy individuals.

Authors:  M Chatterjee; T B Weyandt; R J Frisque
Journal:  J Med Virol       Date:  2000-03       Impact factor: 2.327

5.  The persistence of papovavirus BK DNA sequences in normal human renal tissue.

Authors:  J Heritage; P M Chesters; D J McCance
Journal:  J Med Virol       Date:  1981       Impact factor: 2.327

6.  Effect of transforming growth factor-beta1 on the cell growth and Epstein-Barr virus reactivation in EBV-infected epithelial cell lines.

Authors:  M Fukuda; K Ikuta; K Yanagihara; M Tajima; H Kuratsune; T Kurata; T Sairenji
Journal:  Virology       Date:  2001-09-15       Impact factor: 3.616

7.  Binding of cellular proteins to the regulatory region of BK virus DNA.

Authors:  R B Markowitz; W S Dynan
Journal:  J Virol       Date:  1988-09       Impact factor: 5.103

8.  Molecular characterization and sequence analysis of polyomavirus strains isolated from needle biopsy specimens of kidney allograft recipients.

Authors:  R Boldorini; E Omodeo-Zorini; A Suno; E Benigni; M Nebuloni; E Garino; M Fortunato; G Monga; G Mazzucco
Journal:  Am J Clin Pathol       Date:  2001-10       Impact factor: 2.493

9.  The role of BK virus in acute respiratory tract disease and the presence of BKV DNA in tonsils.

Authors:  J Goudsmit; P Wertheim-van Dillen; A van Strien; J van der Noordaa
Journal:  J Med Virol       Date:  1982       Impact factor: 2.327

10.  Polyomavirus BK with rearranged noncoding control region emerge in vivo in renal transplant patients and increase viral replication and cytopathology.

Authors:  Rainer Gosert; Christine H Rinaldo; Georg A Funk; Adrian Egli; Emilio Ramos; Cinthia B Drachenberg; Hans H Hirsch
Journal:  J Exp Med       Date:  2008-03-17       Impact factor: 14.307
View more
  13 in total

1.  Transforming growth factor beta-induced reactivation of Epstein-Barr virus involves multiple Smad-binding elements cooperatively activating expression of the latent-lytic switch BZLF1 gene.

Authors:  Tawin Iempridee; Shreyasi Das; Iris Xu; Janet E Mertz
Journal:  J Virol       Date:  2011-05-18       Impact factor: 5.103

2.  Stimulation of BK virus DNA replication by NFI family transcription factors.

Authors:  Bo Liang; Irina Tikhanovich; Heinz Peter Nasheuer; William R Folk
Journal:  J Virol       Date:  2011-12-28       Impact factor: 5.103

3.  A system for the analysis of BKV non-coding control regions: application to clinical isolates from an HIV/AIDS patient.

Authors:  Nicole M Broekema; Johanna R Abend; Shauna M Bennett; Janet S Butel; John A Vanchiere; Michael J Imperiale
Journal:  Virology       Date:  2010-09-24       Impact factor: 3.616

Review 4.  Management of polyomavirus-associated nephropathy in renal transplant recipients.

Authors:  Dirk R J Kuypers
Journal:  Nat Rev Nephrol       Date:  2012-04-17       Impact factor: 28.314

5.  Reovirus activates transforming growth factor beta and bone morphogenetic protein signaling pathways in the central nervous system that contribute to neuronal survival following infection.

Authors:  J David Beckham; Kathryn Tuttle; Kenneth L Tyler
Journal:  J Virol       Date:  2009-03-11       Impact factor: 5.103

Review 6.  Regulation of gene expression in primate polyomaviruses.

Authors:  Martyn K White; Mahmut Safak; Kamel Khalili
Journal:  J Virol       Date:  2009-07-29       Impact factor: 5.103

7.  TLR4-Mediated Recognition of Mouse Polyomavirus Promotes Cancer-Associated Fibroblast-Like Phenotype and Cell Invasiveness.

Authors:  Vaclav Janovec; Boris Ryabchenko; Aneta Škarková; Karolína Pokorná; Daniel Rösel; Jan Brábek; Jan Weber; Jitka Forstová; Ivan Hirsch; Sandra Huérfano
Journal:  Cancers (Basel)       Date:  2021-04-25       Impact factor: 6.639

8.  Human BK Polyomavirus Plasmid pBKV (34-2) (Dunlop) Contains Mutations Not Found in the Originally Published Sequences.

Authors:  Stian Henriksen; Christian Mittelholzer; Rainer Gosert; Hans H Hirsch; Christine Hanssen Rinaldo
Journal:  Genome Announc       Date:  2015-03-26

Review 9.  BK nephropathy in the native kidneys of patients with organ transplants: Clinical spectrum of BK infection.

Authors:  Darlene Vigil; Nikifor K Konstantinov; Marc Barry; Antonia M Harford; Karen S Servilla; Young Ho Kim; Yijuan Sun; Kavitha Ganta; Antonios H Tzamaloukas
Journal:  World J Transplant       Date:  2016-09-24

10.  CCL17/TARC and CCR4 expression in Merkel cell carcinoma.

Authors:  Kashif Rasheed; Ibrahim Abdulsalam; Silje Fismen; Øystein Grimstad; Baldur Sveinbjørnsson; Ugo Moens
Journal:  Oncotarget       Date:  2018-07-31
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.