Literature DB >> 18558434

Synthesis, trafficking, and localization of muscarinic acetylcholine receptors.

Neil M Nathanson1.   

Abstract

Muscarinic acetylcholine receptors are members of the G-protein coupled receptor superfamily that are expressed in and regulate the function of neurons, cardiac and smooth muscle, glands, and many other cell types and tissues. The correct trafficking of membrane proteins to the cell surface and their subsequent localization at appropriate sites in polarized cells are required for normal cellular signaling and physiological responses. This review will summarize work on the synthesis and trafficking of muscarinic receptors to the plasma membrane and their localization at the cell surface.

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Year:  2008        PMID： 18558434      PMCID： PMC2579790          DOI： 10.1016/j.pharmthera.2008.04.006

Source DB:  PubMed          Journal:  Pharmacol Ther        ISSN： 0163-7258            Impact factor:   12.310


  145 in total

1.  Native Xenopus oocytes express two types of muscarinic receptors.

Authors:  A Davidson; G Mengod; N Matus-Leibovitch; Y Oron
Journal:  FEBS Lett       Date:  1991-06-24       Impact factor: 4.124

2.  Identification and localization of muscarinic acetylcholine receptor proteins in brain with subtype-specific antibodies.

Authors:  A I Levey; C A Kitt; W F Simonds; D L Price; M R Brann
Journal:  J Neurosci       Date:  1991-10       Impact factor: 6.167

3.  Expression and agonist-induced down-regulation of mRNAs of m2- and m3-muscarinic acetylcholine receptors in cultured cerebellar granule cells.

Authors:  F Fukamauchi; C Hough; D M Chuang
Journal:  J Neurochem       Date:  1991-02       Impact factor: 5.372

4.  Muscarinic acetylcholine receptors are expressed and enriched in growth cone membranes isolated from fetal and neonatal rat forebrain: pharmacological demonstration and characterization.

Authors:  S Saito; Y Komiya; M Igarashi
Journal:  Neuroscience       Date:  1991       Impact factor: 3.590

5.  Localization of the m2 muscarinic acetylcholine receptor protein and mRNA in cortical neurons of the normal and cholinergically deafferented rhesus monkey.

Authors:  L Mrzljak; A I Levey; S Belcher; P S Goldman-Rakic
Journal:  J Comp Neurol       Date:  1998-01-05       Impact factor: 3.215

6.  Developmental regulation of the cm2 muscarinic acetylcholine receptor gene: selective induction by a secreted factor produced by embryonic chick retinal cells.

Authors:  L A McKinnon; E C Gunther; N M Nathanson
Journal:  J Neurosci       Date:  1998-01-01       Impact factor: 6.167

7.  Disruption of the m1 receptor gene ablates muscarinic receptor-dependent M current regulation and seizure activity in mice.

Authors:  S E Hamilton; M D Loose; M Qi; A I Levey; B Hille; G S McKnight; R L Idzerda; N M Nathanson
Journal:  Proc Natl Acad Sci U S A       Date:  1997-11-25       Impact factor: 11.205

8.  Two types of intrinsic muscarinic responses in Xenopus oocytes. II. Hemispheric asymmetry of responses and receptor distribution.

Authors:  N Matus-Leibovitch; M Lupu-Meiri; Y Oron
Journal:  Pflugers Arch       Date:  1990-10       Impact factor: 3.657

9.  Participation of protein kinase C in desensitization to bradykinin and to carbachol in MDCK cells.

Authors:  H Luo; R P Lindeman; H S Chase
Journal:  Am J Physiol       Date:  1992-03

10.  Spatial and temporal distribution of agonist-evoked cytoplasmic Ca2+ signals in exocrine acinar cells analysed by digital image microscopy.

Authors:  E C Toescu; A M Lawrie; O H Petersen; D V Gallacher
Journal:  EMBO J       Date:  1992-04       Impact factor: 11.598
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  27 in total

1.  CaMKIIα, a modulator of M4 muscarinic acetylcholine receptors.

Authors:  Ming-Lei Guo; Zhenguo Liu; Xiang-Ping Chu; Li-Min Mao; John Q Wang
Journal:  Commun Integr Biol       Date:  2010-09

2.  Constitutive internalization of G protein-coupled receptors and G proteins via clathrin-independent endocytosis.

Authors:  Marco Scarselli; Julie G Donaldson
Journal:  J Biol Chem       Date:  2008-11-25       Impact factor: 5.157

Review 3.  Withdrawal symptoms and rebound syndromes associated with switching and discontinuing atypical antipsychotics: theoretical background and practical recommendations.

Authors:  Anja Cerovecki; Richard Musil; Ansgar Klimke; Florian Seemüller; Ekkehard Haen; Rebecca Schennach; Kai-Uwe Kühn; Hans-Peter Volz; Michael Riedel
Journal:  CNS Drugs       Date:  2013-07       Impact factor: 5.749

Review 4.  Non-synaptic receptors and transporters involved in brain functions and targets of drug treatment.

Authors:  E S Vizi; A Fekete; R Karoly; A Mike
Journal:  Br J Pharmacol       Date:  2010-02-05       Impact factor: 8.739

5.  Hippocampal M1 receptor function associated with spatial learning and memory in aged female rhesus macaques.

Authors:  Gwendolen E Haley; Chris Kroenke; Daniel Schwartz; Steven G Kohama; Henryk F Urbanski; Jacob Raber
Journal:  Age (Dordr)       Date:  2010-10-02

6.  Knockouts reveal overlapping functions of M(2) and M(4) muscarinic receptors and evidence for a local glutamatergic circuit within the laterodorsal tegmental nucleus.

Authors:  Kristi A Kohlmeier; Masaru Ishibashi; Jürgen Wess; Martha E Bickford; Christopher S Leonard
Journal:  J Neurophysiol       Date:  2012-09-05       Impact factor: 2.714

Review 7.  Development of M1 mAChR allosteric and bitopic ligands: prospective therapeutics for the treatment of cognitive deficits.

Authors:  Briana J Davie; Arthur Christopoulos; Peter J Scammells
Journal:  ACS Chem Neurosci       Date:  2013-05-23       Impact factor: 4.418

8.  Modeling and analysis of the molecular basis of pain in sensory neurons.

Authors:  Sang Ok Song; Jeffrey Varner
Journal:  PLoS One       Date:  2009-09-11       Impact factor: 3.240

9.  Distinct muscarinic acetylcholine receptor subtypes contribute to stability and growth, but not compensatory plasticity, of neuromuscular synapses.

Authors:  Megan C Wright; Srilatha Potluri; Xueyong Wang; Eva Dentcheva; Dinesh Gautam; Alan Tessler; Jürgen Wess; Mark M Rich; Young-Jin Son
Journal:  J Neurosci       Date:  2009-11-25       Impact factor: 6.167

Review 10.  Muscarinic acetylcholine receptor subtypes in the male reproductive tract: expression and function in rat efferent ductules and epididymis.

Authors:  Maria Christina W Avellar; Erica R Siu; Fabiana Yasuhara; Elisabeth Maróstica; Catarina S Porto
Journal:  J Mol Neurosci       Date:  2009-08-20       Impact factor: 3.444
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