Literature DB >> 1855671

Mitochondrial damage by active oxygen species in vitro.

S Mehrotra1, P Kakkar, P N Viswanathan.   

Abstract

Under in vitro conditions involving formation of active oxygen species, rat liver mitochondria were found to undergo swelling, peroxidative decomposition of lipids, and distinct disorganization of ultrastructure. Supplementation with free radical scavengers such as superoxide dismutase (SOD), methionine, histidine, and tryptophan accorded considerable protection to the organelle. A possible correlation between oxygen radicals, membrane integrity, and calcium functions is indicated.

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Year:  1991        PMID： 1855671     DOI： 10.1016/0891-5849(91)90034-z

Source DB:  PubMed          Journal:  Free Radic Biol Med        ISSN： 0891-5849            Impact factor:   7.376


  14 in total

1.  Inhibition of mitochondrial respiratory chain in the brain of rats after hepatic failure induced by acetaminophen.

Authors:  Jordana P Panatto; Isabela C Jeremias; Gabriela K Ferreira; Andrea C Ramos; Natalia Rochi; Cinara L Gonçalves; Juliana F Daufenbach; Gabriela C Jeremias; Milena Carvalho-Silva; Gislaine T Rezin; Giselli Scaini; Emilio L Streck
Journal:  Mol Cell Biochem       Date:  2011-01-04       Impact factor: 3.396

2.  Interrelation of active oxygen species, membrane damage and altered calcium functions.

Authors:  P Kakkar; S Mehrotra; P N Viswanathan
Journal:  Mol Cell Biochem       Date:  1992-04       Impact factor: 3.396

3.  Alteration in mitochondrial thiol enhances calcium ion dependent membrane permeability transition and dysfunction in vitro: a cross-talk between mtThiol, Ca(2+), and ROS.

Authors:  Brijesh Kumar Singh; Madhulika Tripathi; Pramod Kumar Pandey; Poonam Kakkar
Journal:  Mol Cell Biochem       Date:  2011-07-12       Impact factor: 3.396

4.  tBHP induced in vitro swelling of rat liver mitochondria.

Authors:  P Kakkar; S Mehrotra; P N Viswanathan
Journal:  Mol Cell Biochem       Date:  1996-01-12       Impact factor: 3.396

5.  Diazepam induced early oxidative changes at the subcellular level in rat brain.

Authors:  S Musavi; P Kakkar
Journal:  Mol Cell Biochem       Date:  1998-01       Impact factor: 3.396

Review 6.  Potential therapeutic benefits of strategies directed to mitochondria.

Authors:  Amadou K S Camara; Edward J Lesnefsky; David F Stowe
Journal:  Antioxid Redox Signal       Date:  2010-08-01       Impact factor: 8.401

7.  Influence of some biological response modifiers on swelling of rat liver mitochondria in vitro.

Authors:  S Mehrotra; P N Viswanathan; P Kakkar
Journal:  Mol Cell Biochem       Date:  1993-07-21       Impact factor: 3.396

8.  Killing of endothelial cells and release of arachidonic acid. Synergistic effects among hydrogen peroxide, membrane-damaging agents, cationic substances, and proteinases and their modulation by inhibitors.

Authors:  I Ginsburg; R S Mitra; D F Gibbs; J Varani; R Kohen
Journal:  Inflammation       Date:  1993-06       Impact factor: 4.092

9.  Oxygen radicals generated by the enzyme xanthine oxidase lyse rat pancreatic islet cells in vitro.

Authors:  V Burkart; T Koike; H H Brenner; H Kolb
Journal:  Diabetologia       Date:  1992-11       Impact factor: 10.122

Review 10.  Mitochondria: a hub of redox activities and cellular distress control.

Authors:  Poonam Kakkar; B K Singh
Journal:  Mol Cell Biochem       Date:  2007-06-12       Impact factor: 3.396
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