Literature DB >> 18556468

The role of calmodulin kinase II in myocardial physiology and disease.

Luis F Couchonnal1, Mark E Anderson.   

Abstract

The multifunctional Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) regulates a rich variety of downstream targets in heart. Ca(2+) homeostatic proteins are important CaMKII targets that support myocardial excitation-contraction coupling. Under stress conditions, excessive CaMKII activity promotes heart failure and arrhythmias, in part through actions at Ca(2+) homeostatic proteins. Here, we briefly review the molecular and cellular physiology of CaMKII in myocardium.

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Year:  2008        PMID： 18556468     DOI： 10.1152/physiol.00043.2007

Source DB:  PubMed          Journal:  Physiology (Bethesda)        ISSN： 1548-9221


  63 in total

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