BACKGROUND: Hypertriglyceridemia is a cardiovascular risk factor. Apolipoprotein C-III (apoC-III) is an important determinant of the catabolic rate of triglyceride-rich lipoproteins. The aim of this study was to investigate the prognostic value of plasma apoC-III concentrations for cardiovascular mortality. METHODS: We performed this prospective study in 2244 subjects (ages 49-77 years) who participated in the Hoorn Study. During a mean follow-up of 15 years, 504 individuals died: 231 of cardiovascular disease, 180 of cancer, and 93 of other causes. Cardiovascular disease risk factors and plasma apoC-III concentrations were measured at baseline. RESULTS: The age- and sex-adjusted plasma apoC-III concentration was prospectively associated with cardiovascular mortality (P < 0.001). After adjustment for traditional risk factors, including fasting triglycerides, the hazard ratio (95% CI) for cardiovascular death between the highest and the lowest quartile of apoC-III was 1.85 (1.02-3.38). High concentrations of apoC-III did not appear to be associated with noncardiovascular mortality. CONCLUSIONS: In this general population cohort, a high apoC-III concentration in plasma, independently of fasting triglycerides and other traditional risk factors, predicts cardiovascular mortality.
BACKGROUND:Hypertriglyceridemia is a cardiovascular risk factor. Apolipoprotein C-III (apoC-III) is an important determinant of the catabolic rate of triglyceride-rich lipoproteins. The aim of this study was to investigate the prognostic value of plasma apoC-III concentrations for cardiovascular mortality. METHODS: We performed this prospective study in 2244 subjects (ages 49-77 years) who participated in the Hoorn Study. During a mean follow-up of 15 years, 504 individuals died: 231 of cardiovascular disease, 180 of cancer, and 93 of other causes. Cardiovascular disease risk factors and plasma apoC-III concentrations were measured at baseline. RESULTS: The age- and sex-adjusted plasma apoC-III concentration was prospectively associated with cardiovascular mortality (P < 0.001). After adjustment for traditional risk factors, including fasting triglycerides, the hazard ratio (95% CI) for cardiovascular death between the highest and the lowest quartile of apoC-III was 1.85 (1.02-3.38). High concentrations of apoC-III did not appear to be associated with noncardiovascular mortality. CONCLUSIONS: In this general population cohort, a high apoC-III concentration in plasma, independently of fasting triglycerides and other traditional risk factors, predicts cardiovascular mortality.
Authors: Helen C Looker; Marco Colombo; Felix Agakov; Tanja Zeller; Leif Groop; Barbara Thorand; Colin N Palmer; Anders Hamsten; Ulf de Faire; Everson Nogoceke; Shona J Livingstone; Veikko Salomaa; Karin Leander; Nicola Barbarini; Riccardo Bellazzi; Natalie van Zuydam; Paul M McKeigue; Helen M Colhoun Journal: Diabetologia Date: 2015-03-05 Impact factor: 10.122
Authors: Julian C van Capelleveen; Sophie J Bernelot Moens; Xiaohong Yang; John J P Kastelein; Nicholas J Wareham; Aeilko H Zwinderman; Erik S G Stroes; Joseph L Witztum; G Kees Hovingh; Kay-Tee Khaw; S Matthijs Boekholdt; Sotirios Tsimikas Journal: Arterioscler Thromb Vasc Biol Date: 2017-05-04 Impact factor: 8.311
Authors: Julian C van Capelleveen; Sang-Rok Lee; Rutger Verbeek; John J P Kastelein; Nicholas J Wareham; Erik S G Stroes; G Kees Hovingh; Kay-Tee Khaw; S Matthijs Boekholdt; Joseph L Witztum; Sotirios Tsimikas Journal: J Clin Lipidol Date: 2018-08-29 Impact factor: 4.766
Authors: Chunyu Zheng; Veronica Azcutia; Elena Aikawa; Jose-Luiz Figueiredo; Kevin Croce; Hiroyuki Sonoki; Frank M Sacks; Francis W Luscinskas; Masanori Aikawa Journal: Eur Heart J Date: 2012-08-26 Impact factor: 29.983