OBJECTIVE: To describe three cases of azoospermia in patients with oligospermia after clomiphene citrate (CC) intake. DESIGN: Case report. SETTING(S): Academic medical center. PATIENT(S): Three patients with oligospermia. INTERVENTION(S): Three oligospermic men used CC, resulting in azoospermia. MAIN OUTCOME MEASURE(S): Semen analysis after CC use and after discontinuation of CC. RESULT(S): Three patients were sent to our clinic for investigation of their azoospermia after use of CC. They had severe oligozoospermia (sperm concentrations of 3.4, 2.8, and 4.1 x 10(6)/mL, respectively) before treatment with CC. These patients were re-evaluated with two new semen analyses, showing azoospermia. After 3 months without use of the drug, the mean sperm concentration was 2.5 +/- 1.1 x 10(6)/mL. CONCLUSION(S): The benefits of empiric treatment with CC must be balanced with the possible undesirable effects, such as azoospermia.
OBJECTIVE: To describe three cases of azoospermia in patients with oligospermia after clomiphene citrate (CC) intake. DESIGN: Case report. SETTING(S): Academic medical center. PATIENT(S): Three patients with oligospermia. INTERVENTION(S): Three oligospermic men used CC, resulting in azoospermia. MAIN OUTCOME MEASURE(S): Semen analysis after CC use and after discontinuation of CC. RESULT(S): Three patients were sent to our clinic for investigation of their azoospermia after use of CC. They had severe oligozoospermia (sperm concentrations of 3.4, 2.8, and 4.1 x 10(6)/mL, respectively) before treatment with CC. These patients were re-evaluated with two new semen analyses, showing azoospermia. After 3 months without use of the drug, the mean sperm concentration was 2.5 +/- 1.1 x 10(6)/mL. CONCLUSION(S): The benefits of empiric treatment with CC must be balanced with the possible undesirable effects, such as azoospermia.
Authors: D P Patel; W O Brant; J B Myers; A P Presson; E B Johnstone; J A Dorais; K I Aston; D T Carrell; J M Hotaling Journal: Int J Impot Res Date: 2015-08-20 Impact factor: 2.896