Literature DB >> 18555151

Epidural anesthesia? No of course.

J Fazakas1, Sz Tóth, B Füle, A Smudla, T Mándli, M Radnai, A Doros, B Nemes, L Kóbori.   

Abstract

Although the contraindications for thoracic epidural anesthesia (TEA) are well defined, the debate continues about whether TEA improves outcomes. Pro and con trials and a metaanalysis in the past have yielded equivocal results; they did not deal with new vascular intervention or drugs. The benefit of TEA in surgery is to provide analgesia. In subgroups, TEA can decrease the mortality and morbidity. In contrast, the cost can increase in the situation of a complication that is opposite to the side effects is rare, but the impairment caused by them is out of proportion to the benefits. Primary or secondary prophylaxis with antithrombotic drugs is increasing in developed countries because of the increasing cardiovascular interventions and aging of the population. The neuroaxial guidelines are useful, but the changing of the coagulation profile after hepatectomy is not included in them. The decision to use TEA in liver surgery must be individualized with steps planned from the beginning. TEA suitability is based on an evaluation of the contraindications, comorbidities, coagulation profiles, hepatic reserve, and balance of benefits and risks. The insertion or withdrawal of the epidural catheter should be made with care according to the neuroaxial guidelines and in the presence of a normal TEG. The decreasing level of prothrombin content and platelet counts after hepatectomy should be closely monitored every 2 to 5 days.

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Year:  2008        PMID: 18555151     DOI: 10.1016/j.transproceed.2008.03.109

Source DB:  PubMed          Journal:  Transplant Proc        ISSN: 0041-1345            Impact factor:   1.066


  7 in total

1.  Coagulation profile changes and safety of epidural analgesia after hepatectomy: a retrospective study.

Authors:  Kelly G Elterman; Zhiling Xiong
Journal:  J Anesth       Date:  2014-11-13       Impact factor: 2.078

2.  Postoperative management after hepatic resection.

Authors:  Lindsay J Wrighton; Karen R O'Bosky; Jukes P Namm; Maheswari Senthil
Journal:  J Gastrointest Oncol       Date:  2012-03

3.  [Anesthesiological acute pain therapy in Germany: telephone-based survey].

Authors:  C L Lassen; F Link; N Lindenberg; T W Klier; B M Graf; C Maier; C H R Wiese
Journal:  Anaesthesist       Date:  2013-05-15       Impact factor: 1.041

4.  Thoracic extradural haematoma after epidural anaesthesia.

Authors:  Paolo Perrini; Francesco Pieri; Nicola Montemurro; Giacomo Tiezzi; Giuliano Francesco Parenti
Journal:  Neurol Sci       Date:  2009-10-06       Impact factor: 3.307

5.  Co-existing liver disease increases the risk of postoperative thrombocytopenia in patients undergoing hepatic resection: implications for the risk of epidural hematoma associated with the removal of an epidural catheter.

Authors:  Koichi Takita; Yosuke Uchida; Tetsutaro Hase; Toshiya Kamiyama; Yuji Morimoto
Journal:  J Anesth       Date:  2013-12-29       Impact factor: 2.078

6.  The NAPRESSIM trial: the use of low-dose, prophylactic naloxone infusion to prevent respiratory depression with intrathecally administered morphine in elective hepatobiliary surgery: a study protocol and statistical analysis plan for a randomised controlled trial.

Authors:  David Cosgrave; Marie Galligan; Era Soukhin; Victoria McMullan; Siobhan McGuinness; Anand Puttappa; Niamh Conlon; John Boylan; Rabia Hussain; Peter Doran; Alistair Nichol
Journal:  Trials       Date:  2017-12-29       Impact factor: 2.279

7.  Evaluation of the neurological safety of epidural milnacipran in rats.

Authors:  Seung Mo Lim; Mee Ran Shin; Kyung Ho Kang; Hyun Kang; Francis Sahngun Nahm; Baek Hui Kim; Hwa Yong Shin; Young Jin Lim; Sang Chul Lee
Journal:  Korean J Pain       Date:  2012-10-04
  7 in total

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