Wei-liang Chen1, Hong-jie Feng, Hai-gang Li. 1. Department of Oral and Maxillofacial Surgery, the Second Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China. drchen@vip.136.com
Abstract
OBJECTIVE: The objective of this study was to examine the expression of hypoxia-inducible factor-1alpha (HIF-1alpha) in osteosarcoma of the jaw (OSJ) and its relationships with tumoral angiogenesis and clinicopathologic characteristics. STUDY DESIGN: Streptavidin peroxidase immunohistochemical staining was used to detect the expression of HIF-1alpha and CD34 in paraffin-embedded samples from 25 patients. There were 14 male and 11 female patients, ages ranged from 3 to 63 years. RESULTS: HIF-1alpha was overexpressed in OSJ. HIF-1alpha expression was correlated with tumoral microvascular density, as well as with the size, pathologic grade, and clinical stage of OSJ. Expression of HIF-1alpha was also correlated with clinicopathologic characteristics, such as primary occurrence or recurrence of the tumor, but not with metastasis. CONCLUSION: HIF-1alpha was significantly correlated with the size, pathologic grade, clinical stage, and primary occurrence or recurrence of the OSJ. HIF-1alpha appeared to promote tumoral angiogenesis in OSJ and may be an important target in antitumoral therapy.
OBJECTIVE: The objective of this study was to examine the expression of hypoxia-inducible factor-1alpha (HIF-1alpha) in osteosarcoma of the jaw (OSJ) and its relationships with tumoral angiogenesis and clinicopathologic characteristics. STUDY DESIGN: Streptavidin peroxidase immunohistochemical staining was used to detect the expression of HIF-1alpha and CD34 in paraffin-embedded samples from 25 patients. There were 14 male and 11 female patients, ages ranged from 3 to 63 years. RESULTS:HIF-1alpha was overexpressed in OSJ. HIF-1alpha expression was correlated with tumoral microvascular density, as well as with the size, pathologic grade, and clinical stage of OSJ. Expression of HIF-1alpha was also correlated with clinicopathologic characteristics, such as primary occurrence or recurrence of the tumor, but not with metastasis. CONCLUSION:HIF-1alpha was significantly correlated with the size, pathologic grade, clinical stage, and primary occurrence or recurrence of the OSJ. HIF-1alpha appeared to promote tumoral angiogenesis in OSJ and may be an important target in antitumoral therapy.
Authors: Abdulmlik A Ghashm; Nor H Othman; Mohammed N Khattak; Noorliza M Ismail; Rajan Saini Journal: BMC Complement Altern Med Date: 2010-09-14 Impact factor: 3.659