Literature DB >> 18554916

Study of chemical stability of antivirally active 5-azacytosine acyclic nucleoside phosphonates using NMR spectroscopy.

Martin Dracínský1, Marcela Krecmerová, Antonín Holý.   

Abstract

Hydrolytic decomposition of four 5-azacytosine acyclic nucleoside phosphonates was studied. Products of the decomposition are carbamoylguanidine derivatives. Stability and decomposition products of HPMP-5-azaC (a 5-azacytosine derivative with strong antiviral activity) differ from the other derivatives. The reaction pathway of HPMP-5-azaC involves a formyl derivative formed by intramolecular transformylation reaction.

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Year:  2008        PMID： 18554916     DOI： 10.1016/j.bmc.2008.05.058

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  5 in total

1.  New Phosphorus Analogs of Bevirimat: Synthesis, Evaluation of Anti-HIV-1 Activity and Molecular Docking Study.

Authors:  Elwira Chrobak; Krzysztof Marciniec; Aleksandra Dąbrowska; Paweł Pęcak; Ewa Bębenek; Monika Kadela-Tomanek; Andrzej Bak; Maria Jastrzębska; Stanisław Boryczka
Journal:  Int J Mol Sci       Date:  2019-10-21       Impact factor: 5.923

Review 2.  Phosphonates and Phosphonate Prodrugs in Medicinal Chemistry: Past Successes and Future Prospects.

Authors:  Marcela Krečmerová; Pavel Majer; Rana Rais; Barbara S Slusher
Journal:  Front Chem       Date:  2022-05-20       Impact factor: 5.545

Review 3.  Alpha-carboxynucleoside phosphonates: direct-acting inhibitors of viral DNA polymerases.

Authors:  Jan Balzarini; Alan Ford; Nuala M Maguire; Jubi John; Kalyan Das; Eddy Arnold; Wim Dehaen; Anita Maguire
Journal:  Future Med Chem       Date:  2019-01-16       Impact factor: 3.808

4.  Synthesis and in vitro evaluation of novel acyclic and cyclic nucleoside analogs with a thiadiazole ring.

Authors:  Yuxiang Zhao; Peter J McCarthy; Cyril Párkányi
Journal:  ISRN Org Chem       Date:  2013-03-05

5.  New prodrugs of two pyrimidine acyclic nucleoside phosphonates: Synthesis and antiviral activity.

Authors:  Marcela Krečmerová; Martin Dračínský; Robert Snoeck; Jan Balzarini; Karel Pomeisl; Graciela Andrei
Journal:  Bioorg Med Chem       Date:  2017-07-06       Impact factor: 3.641
  5 in total

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