| Literature DB >> 18554728 |
Aslaug R Lorentzen1, Cathrine Smestad, Benedicte A Lie, Annette B Oturai, Eva Akesson, Janna Saarela, Kjell-Morten Myhr, Frode Vartdal, Elisabeth G Celius, Per S Sørensen, Jan Hillert, Anne Spurkland, Hanne F Harbo.
Abstract
We previously reported an association between the SH2D2A gene encoding TSAd and multiple sclerosis (MS). Here a total of 2128 Nordic MS patients and 2004 controls were genotyped for the SH2D2A promoter GA repeat polymorphism and rs926103 encoding a serine to asparagine substitution at amino acid position 52 in TSAd. The GA(16)-rs926103()A haplotype was associated with MS in Norwegians (OR 1.4, P=0.04). A similar trend was observed among Danes. In the independent Norwegian, Danish and Swedish sample sets the GA(16) allele showed a combined OR of 1.13, P=0.05. Thus, the present study shows that the SH2D2A gene may contribute to susceptibility to MS.Entities:
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Year: 2008 PMID： 18554728 DOI： 10.1016/j.jneuroim.2008.04.037
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478