Luis A Pardo1, Walter Sühmer. 1. Max Planck Institute of Experimental Medicine, Department of Molecular Biology of Neuronal Signals, Hermann-Rein-Str 3, 37075 Göttingen, Germany. pardo@em.mpg.de
Abstract
BACKGROUND: Ion channels are drug targets for many diseases but have only recently started to be regarded as potential primary cancer targets. Many types of ion channels have been identified that could be useful in cancer management. OBJECTIVE: We focus on a voltage-gated potassium channel, ether à go-go 1 (Eag)1, which shows distinctive features such as a restricted expression pattern and peculiar electrophysiological properties. METHODS: We review the literature on this channel and try to relate this knowledge to the context of other ion channels in cancer. RESULTS/ CONCLUSION: Eag1 appears to be a promising cancer target, both as a tumor marker because of restricted expression, which could be useful in the context of therapeutic decisions, and as a therapeutic-agent-targeting molecule.
BACKGROUND: Ion channels are drug targets for many diseases but have only recently started to be regarded as potential primary cancer targets. Many types of ion channels have been identified that could be useful in cancer management. OBJECTIVE: We focus on a voltage-gated potassium channel, ether à go-go 1 (Eag)1, which shows distinctive features such as a restricted expression pattern and peculiar electrophysiological properties. METHODS: We review the literature on this channel and try to relate this knowledge to the context of other ion channels in cancer. RESULTS/ CONCLUSION:Eag1 appears to be a promising cancer target, both as a tumor marker because of restricted expression, which could be useful in the context of therapeutic decisions, and as a therapeutic-agent-targeting molecule.
Authors: Margarita González del Pliego; Elsa Aguirre-Benítez; Karina Paisano-Cerón; Irene Valdovinos-Ramírez; Carlos Rangel-Morales; Verónica Rodríguez-Mata; Carmen Solano-Agama; Dolores Martín-Tapia; María Teresa de la Vega; Miguel Saldoval-Balanzario; Javier Camacho; María Eugenia Mendoza-Garrido Journal: Int J Clin Exp Pathol Date: 2013-02-15
Authors: Roser Ufartes; Tomasz Schneider; Lena Sünke Mortensen; Camino de Juan Romero; Klaus Hentrich; Hendrik Knoetgen; Vadim Beilinson; Wiebke Moebius; Victor Tarabykin; Frauke Alves; Luis A Pardo; J Nicholas P Rawlins; Walter Stuehmer Journal: Hum Mol Genet Date: 2013-02-18 Impact factor: 6.150