| Literature DB >> 18553971 |
Gareth Arnott1, Heloise Brice, Jonathan Clayden, Emma Blaney.
Abstract
Treatment of N-arylisonicotinamides with trifluoromethanesulfonic anhydride triggers intramolecular nucleophilic attack of the aryl ring on the 4-position of the pyridinium intermediate. The products are spirocyclic dihydropyridines which can be converted to valuable spirocyclic piperidines related to biologically active molecules such as MK-677.Entities:
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Year: 2008 PMID： 18553971 DOI： 10.1021/ol801092s
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005