BACKGROUND: The possible association between acute pelvic inflammatory diseases (APID) of pregnant women and structural birth defects, that is, congenital abnormalities (CA) in their offspring, has not been studied. METHODS: The data set of the Hungarian Case-Control Surveillance of Congenital Abnormalities, 1980 and 1996, were evaluated. RESULTS: There were 67 out of 22,843 (0.29%) cases and 128 out of 38,151 (0.34%) controls with mothers who had prospectively and medically recorded APID during the second and/or third gestational months (adjusted prevalence OR with 95% CI: 0.95, 0.70-1.29). However, of 12 CA groups evaluated, APID was associated with a higher risk only for cardiovascular CAs (adjusted prevalence OR with 95% CI: 2.6, 1.2-5.4) and the observed number of cases with atrial septal defect, type II with maternal APID exposure exceeded 4.2-fold its expected number. CONCLUSIONS: A possible explanation for the association of APID with higher risk for cardiovascular CA is the high fever of APID, but this signal finding needs confirmation. Copyright 2008 Wiley-Liss, Inc.
BACKGROUND: The possible association between acute pelvic inflammatory diseases (APID) of pregnant women and structural birth defects, that is, congenital abnormalities (CA) in their offspring, has not been studied. METHODS: The data set of the Hungarian Case-Control Surveillance of Congenital Abnormalities, 1980 and 1996, were evaluated. RESULTS: There were 67 out of 22,843 (0.29%) cases and 128 out of 38,151 (0.34%) controls with mothers who had prospectively and medically recorded APID during the second and/or third gestational months (adjusted prevalence OR with 95% CI: 0.95, 0.70-1.29). However, of 12 CA groups evaluated, APID was associated with a higher risk only for cardiovascular CAs (adjusted prevalence OR with 95% CI: 2.6, 1.2-5.4) and the observed number of cases with atrial septal defect, type II with maternal APID exposure exceeded 4.2-fold its expected number. CONCLUSIONS: A possible explanation for the association of APID with higher risk for cardiovascular CA is the high fever of APID, but this signal finding needs confirmation. Copyright 2008 Wiley-Liss, Inc.
Authors: Emilia H A Koumans; Jennifer Rosen; Melissa K van Dyke; Elizabeth Zell; Christina R Phares; Allan Taylor; John Loft; Stephanie Schrag Journal: Am J Obstet Gynecol Date: 2011-09-08 Impact factor: 8.661
Authors: Tonia C Carter; Richard S Olney; Allen A Mitchell; Paul A Romitti; Erin M Bell; Charlotte M Druschel Journal: Birth Defects Res A Clin Mol Teratol Date: 2010-12-07
Authors: Jenil Patel; Emine Bircan; Xinyu Tang; Mohammed Orloff; Charlotte A Hobbs; Marilyn L Browne; Lorenzo D Botto; Richard H Finnell; Mary M Jenkins; Andrew Olshan; Paul A Romitti; Gary M Shaw; Martha M Werler; Jingyun Li; Wendy N Nembhard Journal: PLoS Genet Date: 2021-03-08 Impact factor: 5.917