B Herrlin1, C Sylvén. 1. Department of Medicine, Huddinge Hospital, Sweden.
Abstract
STUDY OBJECTIVE: The aim was to determine whether there is a compensatory increase in arterial oxygen content to a hypokinetic circulation in ambulant patients with chronic moderate heart failure caused by dilated cardiomyopathy. DESIGN - Central haemodynamics, arterial oxygen content, arterial haemoglobin concentration, arterial oxygen saturation, and blood gases were measured during a 6 min supine exercise test on a symptom related submaximal workload. At rest, total body haemoglobin was determined. PATIENTS: 19 patients with chronic stable moderate heart failure caused by dilated cardiomyopathy, treated with diuretics and digoxin, were studied. MEASUREMENTS AND MAIN RESULTS: During exercise arterial oxygen content correlated inversely with the cardiac index (r = 0.66, p less than 0.01). The two determinants of arterial oxygen content, arterial haemoglobin concentration and arterial oxygen saturation, also correlated inversely with the cardiac index (r = 0.60, p less than 0.01 and r = 0.70, p less than 0.001 respectively). Cardiac index during exercise correlated inversely with total body haemoglobin (r = 0.73, p less than 0.001). CONCLUSIONS: A hypokinetic circulation during daily living induces an increase in arterial oxygen content in patients with chronic stable moderate heart failure caused by dilated cardiomyopathy. Renal hypoperfusion may play a role in stimulating the erythropoiesis and exertional hyperventilation in raising arterial oxygen saturation.
STUDY OBJECTIVE: The aim was to determine whether there is a compensatory increase in arterial oxygen content to a hypokinetic circulation in ambulant patients with chronic moderate heart failure caused by dilated cardiomyopathy. DESIGN - Central haemodynamics, arterial oxygen content, arterial haemoglobin concentration, arterial oxygen saturation, and blood gases were measured during a 6 min supine exercise test on a symptom related submaximal workload. At rest, total body haemoglobin was determined. PATIENTS: 19 patients with chronic stable moderate heart failure caused by dilated cardiomyopathy, treated with diuretics and digoxin, were studied. MEASUREMENTS AND MAIN RESULTS: During exercise arterial oxygen content correlated inversely with the cardiac index (r = 0.66, p less than 0.01). The two determinants of arterial oxygen content, arterial haemoglobin concentration and arterial oxygen saturation, also correlated inversely with the cardiac index (r = 0.60, p less than 0.01 and r = 0.70, p less than 0.001 respectively). Cardiac index during exercise correlated inversely with total body haemoglobin (r = 0.73, p less than 0.001). CONCLUSIONS: A hypokinetic circulation during daily living induces an increase in arterial oxygen content in patients with chronic stable moderate heart failure caused by dilated cardiomyopathy. Renal hypoperfusion may play a role in stimulating the erythropoiesis and exertional hyperventilation in raising arterial oxygen saturation.
Authors: Bryan J Taylor; Cesar R Mojica; Thomas P Olson; Paul R Woods; Robert P Frantz; Bruce D Johnson Journal: J Card Fail Date: 2013-01 Impact factor: 5.712