H Tong1, E Isenring, P Yates. 1. Queensland University of Technology, Brisbane, Queensland, 4059, Australia.
Abstract
GOALS OF WORK: The aims of this secondary analysis were to determine the prevalence of nutrition impact symptoms in medical oncology patients at 1, 6, and 12 months after commencement of chemotherapy and to investigate the relationship of these symptoms to quality of life (QoL) and performance status. MATERIALS AND METHODS: A prospective longitudinal survey was conducted in 219 medical oncology patients who had commenced chemotherapy in the past month. The Rotterdam Symptom Assessment scale assessed the number and distress level of symptoms. The association between symptoms and global QoL and performance status as measured by the Life Satisfaction Scale was investigated. MAIN RESULTS: Symptom prevalence as determined by the proportion of patients experiencing at least one nutrition impact symptom was 79% and 72% at 1 and 6 months after starting chemotherapy. Even at 12 months, symptom prevalence was 46%. The most common symptoms included dry mouth, nausea, and constipation with the most distressing symptoms reported as dry mouth, diarrhea, and stomach pain. A higher number of symptoms was associated with lower QoL (T1: r = -0.35, n = 217, P < 0.05; T2: r = -0.406, n = 194, P < 0.001; T3: r = -0.353, n = 157, P < 0.001). Patients experiencing more symptoms were more likely to have lower performance status at T2 and T3 (T2: n = 189, P = 0.019; T3: n = 143, P = 0.003). CONCLUSION: Nutrition impact symptoms were commonly experienced, even 12 months following commencement of chemotherapy, and were associated with poorer QoL and performance status. This highlights the importance of early identification and management of nutrition impact symptoms with adequate follow-up in order to provide optimal care for people with cancer.
GOALS OF WORK: The aims of this secondary analysis were to determine the prevalence of nutrition impact symptoms in medical oncology patients at 1, 6, and 12 months after commencement of chemotherapy and to investigate the relationship of these symptoms to quality of life (QoL) and performance status. MATERIALS AND METHODS: A prospective longitudinal survey was conducted in 219 medical oncology patients who had commenced chemotherapy in the past month. The Rotterdam Symptom Assessment scale assessed the number and distress level of symptoms. The association between symptoms and global QoL and performance status as measured by the Life Satisfaction Scale was investigated. MAIN RESULTS: Symptom prevalence as determined by the proportion of patients experiencing at least one nutrition impact symptom was 79% and 72% at 1 and 6 months after starting chemotherapy. Even at 12 months, symptom prevalence was 46%. The most common symptoms included dry mouth, nausea, and constipation with the most distressing symptoms reported as dry mouth, diarrhea, and stomach pain. A higher number of symptoms was associated with lower QoL (T1: r = -0.35, n = 217, P < 0.05; T2: r = -0.406, n = 194, P < 0.001; T3: r = -0.353, n = 157, P < 0.001). Patients experiencing more symptoms were more likely to have lower performance status at T2 and T3 (T2: n = 189, P = 0.019; T3: n = 143, P = 0.003). CONCLUSION: Nutrition impact symptoms were commonly experienced, even 12 months following commencement of chemotherapy, and were associated with poorer QoL and performance status. This highlights the importance of early identification and management of nutrition impact symptoms with adequate follow-up in order to provide optimal care for people with cancer.
Authors: U Khalid; A Spiro; C Baldwin; B Sharma; C McGough; A R Norman; T Eisen; M E R O'Brien; D Cunningham; H J N Andreyev Journal: Support Care Cancer Date: 2006-06-20 Impact factor: 3.603
Authors: Digant Gupta; Christopher G Lis; Joel Granick; James F Grutsch; Pankaj G Vashi; Carolyn A Lammersfeld Journal: J Clin Epidemiol Date: 2006-04-19 Impact factor: 6.437
Authors: K W Schuit; D T Sleijfer; W J Meijler; R Otter; J Schakenraad; F C van den Bergh; B Meyboom-de Jong Journal: J Pain Symptom Manage Date: 1998-11 Impact factor: 3.612
Authors: Elisabeth Isenring; Giordana Cross; Lynne Daniels; Elizabeth Kellett; Bogda Koczwara Journal: Support Care Cancer Date: 2006-04-19 Impact factor: 3.359
Authors: Mercè Planas; Julia Álvarez-Hernández; Miguel León-Sanz; Sebastián Celaya-Pérez; Krysmarú Araujo; Abelardo García de Lorenzo Journal: Support Care Cancer Date: 2015-06-23 Impact factor: 3.603
Authors: Grant R Williams; Mustafa Al-Obaidi; Chen Dai; Nabiel Mir; Sai Alekha Challa; Michael Daniel; Harita Patel; Brett Barlow; Crystal Young-Smith; Olumide Gbolahan; Ravi Paluri; Smita Bhatia; Smith Giri Journal: Cancer Date: 2020-09-04 Impact factor: 6.860
Authors: Asta Bye; Marit S Jordhøy; Grete Skjegstad; Oddlaug Ledsaak; Per Ole Iversen; Marianne Jensen Hjermstad Journal: Support Care Cancer Date: 2012-06-10 Impact factor: 3.603
Authors: Eran Ben-Arye; Yael Keshet; Inbar Miller Shahbar; Michal Livne Aharonson; Liora Preis; Olga Agour; Elad Schiff; Noah Samuels Journal: Support Care Cancer Date: 2015-09-11 Impact factor: 3.603