Literature DB >> 18550664

Liver-specific microRNA miR-122 enhances the replication of hepatitis C virus in nonhepatic cells.

Jinhong Chang1, Ju-Tao Guo, Dong Jiang, Haitao Guo, John M Taylor, Timothy M Block.   

Abstract

The liver-specific microRNA miR-122 has been shown to be required for the replication of hepatitis C virus (HCV) in the hepatoma cell line Huh7. The aim of this study was to test if HCV replication can be modulated by exogenously expressed miR-122 in human embryonic kidney epithelial cells (HEK-293). Our results demonstrate that miR-122 enhances the colony formation efficiency of the HCV replicon and increases the steady-state level of HCV RNA in HEK-293 cells. Therefore, we conclude that although miR-122 is not absolutely required, it greatly enhances HCV replication in nonhepatic cells.

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Year:  2008        PMID: 18550664      PMCID: PMC2519557          DOI: 10.1128/JVI.02575-07

Source DB:  PubMed          Journal:  J Virol        ISSN: 0022-538X            Impact factor:   5.103


  49 in total

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