| Literature DB >> 18550664 |
Jinhong Chang1, Ju-Tao Guo, Dong Jiang, Haitao Guo, John M Taylor, Timothy M Block.
Abstract
The liver-specific microRNA miR-122 has been shown to be required for the replication of hepatitis C virus (HCV) in the hepatoma cell line Huh7. The aim of this study was to test if HCV replication can be modulated by exogenously expressed miR-122 in human embryonic kidney epithelial cells (HEK-293). Our results demonstrate that miR-122 enhances the colony formation efficiency of the HCV replicon and increases the steady-state level of HCV RNA in HEK-293 cells. Therefore, we conclude that although miR-122 is not absolutely required, it greatly enhances HCV replication in nonhepatic cells.Entities:
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Year: 2008 PMID: 18550664 PMCID: PMC2519557 DOI: 10.1128/JVI.02575-07
Source DB: PubMed Journal: J Virol ISSN: 0022-538X Impact factor: 5.103